Cardiovascular Tissue Engineering and Regenerative Medicine Lab
Selected Journal Publications
These articles may be found online at Pubmed or using the links below. Free Articles can be accessed using the PMCID links.
  1. J Dhulekar, A Simionescu. “Challenges in vascular tissue engineering for diabetic patients”. Acta Biomaterialia. (2018); 70:25-34. 29396167. PMCID: PMC5871600

  2. J Chow, D Simionescu, AL Carter, A Simionescu. “Immunomodulatory effects of autologous adipose tissue-derived stem cells on vascular scaffold remodeling in diabetes”. Tissue Engineering and Regenerative Medicine. (2016); 13(6): 701-712. Abstract

  3. C Deborde, D Simionescu, J Liao, L Sierad, C Wright, A Simionescu. “Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering”. Tissue Engineering, Part A. (2016); 22(21-22):1241-1251. 27608885

  4. M Harpa, I Movileanu, L Sierad, O Cotoi, H Suciu, T Preda, D Nistor, C Sircuta, K Branzaniuc, R Deac, S Gurzu, L Harceaga, P Olah, D Simionescu, M Dandel, A Simionescu. “In vivo testing of xenogeneic acellular aortic valves seeded with stem cells”. Romanian Review of Laboratory Medicine. (2016); 24(3). In press.

  5. Chawla V, Simionescu A, Langan EM III, LaBerge M. “Influence of clinically relevant mechanical forces on vascular smooth muscle cells under chronic high glucose: An In Vitro Dynamic Disease Model”. Annals of Vascular Surgery. (2016); 34: 212-226. 27126714

  6. A Kennamer, L Sierad, R Pascal, N Rierson, C Albers, M Harpa, O Cotoi, L Harceaga, P Olah, P Terezia, A Simionescu, D Simionescu. “Bioreactor conditioning of valve scaffolds seeded internally with adult stem cells”. Tissue Engineering and Regenerative Medicine. (2016); 13(5): 507-515. Abstract

  7. M Harpa, I Movileanu, L Sierad, O Cotoi, H Suciu, C Sircuta, T Preda, D Nistor, K Branzaniuc, R Deac, M Dandel, S Gurzu, L Harceaga, P Olah, A Simionescu, D Simionescu. “Pulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds; effects of seeding with autologous stem cells”. Romanian Review of Laboratory Medicine. (2015); 23(4). Full Text.

  8. L Sierad, EL Shaw, A Bina, B Brazile, N Rierson, S Patnaik, A Kennamer, R Odum, O Cotoi, T Preda, K Branzaniuc, H Smallwood, R Deac, I Egyed, Z Pavai, A Szanto, L Harceaga, H Suciu, V Raicea, P Olah, A Simionescu, J Liao, I Movileanu, M Harpa, D. Simionescu. “Functional heart valve scaffolds obtained by complete decellularization of porcine aortic roots in a novel differential pressure gradient perfusion system”. Tissue Engineering, Part C. (2015); 21(12); 1284-1296. 26467108. PMCID: PMC4663650

  9. M Harpa, K Branzaniuc, I Movileanu, O Cotoi, H Suciu, R Deac, L Harceaga, A Simionescu, D Simionescu. “Implantation of valvular collagen biomaterials seeded with autologous stem cells – intraoperative hemodynamic measurements in an animal model”. Acta Medica Transylvanica. (2015); 20(2): 38-39. Abstract.

  10. T Pennel, G Fercana, D Bezuidenhout, A Simionescu, T Chuang, P Zilla, D Simionescu. “The Performance of Cross-linked Acellular Arterial Scaffolds as Vascular Grafts; Pre-clinical Testing in Direct and Isolation Loop Circulatory Models”. Biomaterials. (2014); 35(24); 6311-22. 24816365. PMCID: PMC4048826

  11. Mattix BM, Olsen TR, Casco M, Reese L, Poole JT, Zhang J, Visconti RP, Simionescu A, Simionescu DT, Alexis F. "Janus magnetic cellular spheroids for vascular tissue engineering". Biomaterials. (2014); 35(3): 949-960. 24183699. PMCID: PMC4734748

  12. T Larrew, J Chow, J Schulte, D Simionescu, A Simionescu. “The roles of various metabolic enzymes in diabetic cardiomyopathy—in vivo and in vitro approach”. Cardiovascular Pathology. (2013); 22(3): e48. Abstract.

  13. JB Schulte, A Simionescu, DT Simionescu. “The Acellular Myocardial Flap; a Novel Extracellular Matrix Scaffold Enriched with Patent Microvascular Networks and Biocompatible Cell Niches”. Tissue Engineering. (2013); 19(7): 518-530. 23151037. PMCID: PMC3662386.

  14. JP Chow, DT Simionescu, H Warner, B Wang, SS Patnaik, J Liao, A Simionescu. “Mitigation of Diabetes-Related Complications in Implanted Collagen and Elastin Scaffolds Using Matrix-Binding Polyphenol”. Biomaterials. (2013); 34(3): 685-695.23103157. PMCID: PMC3496025.

  15. D Simionescu, M Jaeggli, J Liao, A Simionescu. “Translational personalized regenerative medicine; scaffolds and stem cells for patient-tailored aortic heart valve tissue engineering”. Cardiology (2012); 121: 138.

  16. Tedder ME, Liao J, Simionescu A, Simionescu DT, “Assembly and testing of layered collagen constructs for heart valve tissue engineering”. Tissue Engineering, Part A. (2011); 17(1-2): 25-36. 20673028. PMCID: PMC3011922.

  17. A Simionescu, Mary E. Tedder, Ting-Hsien Chuang, D. Simionescu. “Lectin and Antibody-Based Histochemical Techniques For Cardiovascular Tissue Engineering”. Journal of Histotechnology (April 2011); 34(1): 20-28. 25620822. PMCID: PMC4303246.

  18. A. Simionescu, JB Schulte, G Fercana, DT Simionescu, “Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview,” International Journal of Inflammation, vol. 2011 (2011); Article ID 958247, 11 pages. 21755031. PMCID: PMC3132660.

  19. Leslie N. Sierad, Christopher Albers, Jordan Maivelett, Mary E. Tedder, Jun Liao, D. Simionescu, A Simionescu, “Endothelialization of decellularized penta-galloyl-glucose treated xenograft scaffolds and dynamic conditioning in a heart valve bioreactor”, Cardiovascular Engineering and Technology (2010); 1(2): 138-153. Abstract.

  20. M. E. Plonska-Brzezinska, A. Palkar, K. Winkler, A. Simionescu, D. Simionescu, A. Dubis, A. J. Athans, L. Echegoyen, “Small non-cytotoxic carbon nano-onions: investigation of the electrochemical behavior and their potential application”. Chemistry (2010); 16(16): 4870-4880.

  21. Tedder ME, Liao J, Weed B, Stabler C, Zhang H, Simionescu A, Simionescu DT. “Stabilized collagen scaffolds for heart valve tissue engineering”. Tissue Engineering Part A. (2009); 15(6): 1257-1268. 18928400 . PMCID: PMC2792094.

  22. Chuang TH, Stabler C, Simionescu A, Simionescu DT. “Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts”. Tiss Eng Part A. (2009); 15(10): 1257-1268. 19254115. PMCID: PMC2792047.

  23. Simionescu A, Simionescu D, Vyavahare NR. “Osteogenic responses in fibroblasts activated by elastin degradation products and TGF-ß1: role of myofibroblasts in vascular calcification” American Journal of Pathology (2007); 171(1): 116-23. 17591959. PMCID: PMC1941602.

  24. Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu D, Vyavahare NR. “Elastin Calcification in the Rat Subdermal Model Is Accompanied by Up-Regulation of Degradative and Osteogenic Cellular Responses”. American Journal of Pathology (2006); 168(2): 490-8. 16436663. PMCID: PMC1606489.

  25. Lu Q, Simionescu A, Vyavahare NR. “Novel capillary channel fiber scaffolds for guided tissue engineering”. Acta Biomater. (2005 Nov); 1(6): 607-14. 16701841.

  26. Simionescu A, Philips K, Vyavahare N. "Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells". Biochem Biophys Res Commun. (2005); 334(2): 524-532. 16005428.

  27. Simionescu A, Simionescu D, Deac R. "Matrix metalloproteinases in the pathology of natural and bioprosthetic cardiac valves". Cardiovascular Pathology (1996); 5: 323-332. Abstract.

  28. Simionescu D, Deac R, Simionescu A. "Inhibition of extracellular-matrix degrading proteases in pericardial derived cardiovascular bioprostheses". Journal of Material Science; Materials in Medicine (1994); 5 (9-10): 748-751. Abstract.

  29. Simionescu A, Simionescu D, Deac R. "Lysine-enhanced glutaraldehyde crosslinking of collagenous biomaterials". Journal of Biomedical Materials Research (1991); 25(12): 1495-1505. 1794997.
Books and Monographs
  1. Dan Simionescu, Agneta Simionescu, book editors. InTech - Open Access Publisher, Rijeka, Croatia. Title, “Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy”. ISBN 978-953-51-3023-6. (April 2017).
     
  2. Dan Simionescu, Agneta Simionescu, book editors. InTech - Open Access Publisher, Rijeka, Croatia. Title, “Vasculogenesis and Angiogenesis – from Embryonic Development to regenerative Medicine”. ISBN 978-953-307-882-3. (November 2011).
     
  3. Simionescu D, Simionescu Agneta, Deac R, "Molecular pathology of biomaterials, in "Cell adhesion and the extracellular matrix". C. Cruce, Agneta Simionescu, D. Simionescu et.al (eds), AIUS Publishers, Craiova, Romania, 1997 (in Romanian).

Patents
  1. “Method and kit for rapid preparation of autologous tissue medical devices”. US/World, Patent #6,214,055/USPTO, (2001) with D. Simionescu, R. Deac.

  2. “Pre-vascularized scaffold for muscle tissue regeneration and method to obtain such biomaterial”. Provisional patent application CURF Ref. No. #2011-093; MBSS Ref. No. 9662-22PR. (2012). With Jason Schulte and D. Simionescu.

  3. “Treatment to Render Implants Resistant to Diabetes”. Provisional patent application. (February 2013). With James Chow and D. Simionescu.

  4. Disclosures to CURF (Clemson University Research Foundation):
        a. CURF ID 2011-107: "Perfusion Tissue Processor/Bioreactor for Preparing Myocardial Scaffolds"
        b. CURF ID 2011-093: "Pre-vascularized Scaffold for Muscle Tissue Regeneration and Method to Obtain Such Biomaterial"
        c. CURF ID 2012-057: "Treatment to render implants resistant to diabetes"
        d. “Magnetic Printing of Viable Cell Spheroids.” Disclosure (2012).
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