Rapid expansion of sub- and supercritical solutions into liquid solvents (RESOLV) process for encapsulation of bioactive agents in polymeric nanoparticles


Rapid expansion of sub- and supercritical solutions into liquid solvents (RESOLV) process has been used to fabricate bioactive compound-loaded polymeric nanoparticles with tunable particle size, loading capacity, and release profile. Renewable biopolymers such as poly(L-lactide) and lignins are being investigated as encapsulating matrices for natural oxidative labile bioactive agents (e.g., catechins and curcuminoids).



Figure 1. Schematic of the phase-behavior and RESOLV apparatus.




Collaborators
John Blackburn and Michael Lake Liquid Lignin Co.
Alex Briseño UMass Amherst
Robert Enick Pittsburgh
David Hodge Michigan State
Wes Hoffman AFRL
James Klett ORNL
Amporn Sane Kasetsart Univ.
Jeremy Smith ORNL
Jim Watkins UMass Amherst

David Bruce, Ken Marcus, Amod Ogale, Mark Roberts, Yi Zheng Clemson



Funding Sources