Rapid expansion of sub- and supercritical solutions into liquid solvents (RESOLV) process has been used to fabricate bioactive compound-loaded polymeric nanoparticles with tunable particle size, loading capacity, and release profile. Renewable biopolymers such as poly(L-lactide) and lignins are being investigated as encapsulating matrices for natural oxidative labile bioactive agents (e.g., catechins and curcuminoids).

Figure 1. Schematic of the phase-behavior and RESOLV apparatus.