High performance computing has been and will continue to be a key ingredient in America's innovation capacity. It accelerates the innovation process by shrinking "time-to-insight" and "time-to-solution" for both discovery and invention. Along with theory and experimentation, modeling and simulation with high performance computers has become the third leg of science and the path to competitive advantage. With the help of high performance computing, innovations not yet imagined may enable us to achieve medical breakthroughs that lead to significantly better health across the planet; reduce substantially the design and development cycles for high-value products and services; develop affordable, environmentally-friendly alternative sources of energy; and expand access to the knowledge that can enable a more secure and satisfying future. High Performance Computing: Accelerating Innovation for Prosperity, builds on the realization that in a highly linked, competitive global environment, out-compete increasingly means out-compute. Participants will explore cutting edge problems that industry must solve to stay at the forefront of global competition, but that require even more computational capability than is available today to address them successfully. And because "extreme innovation" cannot take place without state-of-the-art application software to take advantage of the enhanced performance of these powerful systems, conference participants also will examine options for bridging the chasm between the software we have, and the software we need to drive more aggressive use of High Performance Computing across all industries. America's capacity to innovate is the foundation for bringing our competitiveness to full fruition. Using high performance computing systems, America can unleash a new era of innovation-driven growth, creating new industries and markets, fueling wealth creation and profits, and generating high-value, higher-paying jobs to raise the standard of living for all of our citizens.