Simulation Software

Automatic Generation of Lumped Parameter Cardiovascular Physiology Model

This software will construct and run a realistic closed-loop lumped-parameter model of cardiovascular physiology. The software automatically tunes the model parameters to achieve a set of desired hemodynamic outputs specified by the user, including: Systolic aortic pressure, diastolic aortic pressure, heart rate, systolic left ventricular volume, diastolic left ventricular volume, systolic right ventricular volume, diastolic right ventricular volume.
The software will set model parameters such that all other hemodynamic outputs and waveforms not specified by the user will fall within realistic clinical ranges.
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Fontan Exercise Physiology Model

This package contains the source codes for running 0D lumped-parameter simulations to model Fontan exercise physiology. The model inputs are patient weight, height, and exercise intensity. The model then performs a simulation to produce the presure, flow, and volume waveforms at various anatomical locations for the average Fontan patient with those input characteristics.
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Physiologic Waveforms

Abdominal Aorta & Renal Arteries

This data contains realistic physiologic waveforms for the renal flow and the infra-renal aortic flow, as well as for the abdominal aortic pressure. Two physiological conditions are included: resting and light exercise. The data represents a normal adult, and is based on simulations which use realistic aortic flows and renal/iliac outlet impedances.
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Reference: Kung E, Les AS, Medina F, Wicker RB, McConnell MV, Taylor CA, “In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions.” J Biomech Eng. 133(4):041003 (2011)

Fontan Exercise

This dataset contains simulated physiologic flow, pressure, and volume information at various anatomical locations for two example Fontan patients at rest and at 5 graded levels of exercise.
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Reference: Kung E, Pennati G, Migliavacca F, Hsia TY, Marsden A, Giardini A, MOCHA Investigators, “A Simulation Protocol For Exercise Physiology In Fontan Patients Using A Closed-Loop Lumped-Parameter Model.” Journal of Biomechanical Engineering. 136(8):081007 (2014)

Matlab Codes

PCMRI DICOM to VTK Converter

This Matlab code converts phase-contrast MRI DICOM data into VTK files for easy visualization and manipulation. The code can handle 1-component or 3-component PCMRI DICOM data.
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Design & Geometries

Abdominal Aortic Aneurysm flow phantom

This package contains Parasolid files which can be directly used in a rapid-prototyping machine to print an AAA flow phantom for experiments. The geometry can also be directly used in a CFD simulation of blood flow. The phantom geometry is based on a patient-specific AAA, and contains the beginning segments of the renal and iliac arteries. The phantom has one inlet and two outlets.
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Abdominal Aortic Aneurysm flow phantom

Reference: Kung E, Les AS, Medina F, Wicker RB, McConnell MV, Taylor CA, “In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions.” J Biomech Eng. 133(4):041003 (2011)

Physical Resistor-Capacitor-Resistor Module

This package contains Solidworks files with the design to construct a physical RCR module for reproducing realistic vascular impedances for flow experiments. The design allows for a stable operation and accurate adjustment of the resulting impedance. The capacitor module assembly contains an inlet region to minimize parasitic resistance, allowing it to perform closely as an ideal capacitor.
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Physical Resistor-Capacitor-Resistor Module

Reference: Kung E, Taylor C, “Development of a Physical Windkessel Module to Re-Create In Vivo Vascular Flow Impedance for In Vitro Experiments.” Cardiovascular Engineering and Technology. 2(1):2-14 (2011)

Fun Stuff