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Research Cores

One of the major goals of the SC TRIMH Center is to improve the capacity and capabilities of the infrastructure and resources available to investigators to perform cutting-edge musculoskeletal health research, and medical research in general, at Clemson and across the state and southeast.

The SC TRIMH Research Cores were developed by leveraging Clemson’s existing strengths in biophysics/computational modeling, advanced additive/subtractive manufacturing and systems analysis and assessment, and preclinical modeling and functional assessment, into three comprehensive Research Cores. Please see below for descriptions of the Cores and how they may benefit your research.


Hai Yao, Director
William Richardson, Co‑Director
Feng Ding, Resource Mentor
Multiscale Computational Modeling Core

Objective: Support to build patient-specific and precision-care musculoskeletal systems through multiscale modeling at molecular, cellular, tissue, and body levels.

Aims:
  1. Develop, Acquire, Maintain software tools/packages
  2. Utilize palmetto Cluster
  3. Mentoring in Multiscale Modeling
  4. Go-to Place for Multiscale and Multi-discipline computational modeling

Services
  • High-performance graphic workstations for imaging-based model creation (pre-processing) and simulation results visualization (post-processing).
  • High-performance computing workstations for computational model solver optimization.
  • Commercial software licenses and modeling software capacities through open-source codes like FEBio (finite element analysis), OpenSim (multibody dynamics), and 3D slicer (imaging processing).
  • Full access to high-performance computing and data visualization capacities at Clemson through Clemson Cyberinfrastructure Technology Integration (CITI) Group within Clemson.
  • Support team to provide general and project-specific assistances in multiscale computational – molecular, cellular, tissue-level modeling.
  • Capacities on pre and post-processing in computational modeling.
  • COMSOL, ABQUS, ANSYS, FLUENT, etc., + multibody human dynamics modeling using AnyBody and OpenSim, probabilistic modeling using Molecular Dynamics codes, and image-based patient-specific modeling using Amira, Mimics, and Simpleware.

To request service, please submit the MCM Core Service Request Form to:
Hai Yao (Director), haiyao@clemson.edu
Hai Xiao, Director
Georges Fadel, Co‑Director
Advanced Fabrication and Testing Core

Objective: Provide investigators a centralized resource for 3D model-based design, rapid prototyping, and advanced testing to facilitate musculoskeletal research.

Aims:
  1. Using 3-D Design and Rapid prototyping, enable investigators to create components required to perform virtual human trials.
  2. Assist investigators in design, fabrication, installation and validation of sensors into physical/biological replica for in situ testing and preclinical testing.
  3. Become the preeminent source for rapid fabrication and testing for musculoskeletal health in SC.

To request service, please submit the AFT Core Service Request Form to:
Hai Xiao (Director), haix@clemson.edu
Jeryl Jones, Director
Michael Kissenberth, Co‑Director
Pre-clinical Assessment Core

Objective: Provide mentoring and strategic planning for the use of live large animal models and/or human cadaver models in their research programs to enhance research and innovation competitiveness in the field of musculoskeletal health.

Aims:
  1. Expertise and support for pre-clinical animal modeling.
  2. Facilitators for junior investigators to develop pre-clinical models (animal and human cadavers).
  3. Enhance capabilities and grow pre-clinical research activities.

To request service, please submit the PAC Core Service Request Form to:
Jeryl Jones (Director), jerylj@clemson.edu