Laboratory of Orthopaedic Tissue Regeneration and Orthobiologics


Journal Publications

  1. Ren, P., Chen, P, Reeves, R., Buchweitz, N., Niu, H, Gong, H., Mercuri, J., Reitman, C., Yao, H., Wu, Y. “Diffusivity of human cartilage endplates in healthy and degenerated intervertebral discs.” Journal of Biomechanical Engineering. Feb. (2023). 8:1-27.
  2. Sawvell, E., Wright, N., Ode, G., Mercuri, J. “Perinatal tissue derived allografts and stromal cells for the treatment of knee osteoarthritis: A review of pre-clinical and clinical evidence.” Cartilage. Dec. (2022). 13(4):184-199.
  3.  Kwapisz, A., Bowman, M., Walters, J., Cosh, H., Burnikel, B., Tokish, J., Ye, T., Mercuri, J. “Human adipose and amnion derived mesenchymal stromal cells similarly mitigate osteoarthritis progression in the dunkin hartley guinea pig.” American Journal of Sports Medicine. Dec. (2022). 50(14): 3963- 3973.
  4.  Tokish, J., Shaha, J., Denard, P., Mercuri, J., Colbath, G. “Compressed biceps autograft augmentation of arthroscopic rotator cuff repair.” Arthroscopy Techniques. Nov. (2022). 11(11): E2113-E2118.
  5.  Wang, B., Sierad, L., Mercuri, J., Simionescu, A., Simionescu, D., Williams, L., Vela, R., Bajona, P., Peltz, M., Ramaswamy, S., Hong, Y., Liao, J. “Structural and biomechanical characterizations of acellular porcine mitral valve scaffolds: anterior leaflets, posterior leaflets, and chordae tendineae. Engineered Regeneration. Aug. (2022). 3:374-386.
  6. Borem, R., Madeline, A., Theos, C., Vela, R., Garon, A., Gill, S., Mercuri, J. “Angle-ply scaffold supports annulus fibrosus matrix expression and remodeling by mesenchymal stromal and annulus fibrosus cells." Journal of Biomedical Materials Research – Part B. May. (2022). 110(5):1056-1068. .
  7. Colbath, G., Murray, A., Siatkowski, S., Pate, T., Krussig, M., Pill, S., Hawkins, R., Tokish, J., Mercuri, J. “Autograft long head biceps tendon can be used as a scaffold for biologically augmenting rotator cuff repairs.” Journal of Arthroscopy and Related Research. Jan. (2022). 38(1):38-48. PMC8665938.
  8. Jones, J., Harrison, C., Harbold, A., Bridges, W., Mercuri, J. “Open-source image analysis software yields reproducible MRI measures of lumbar intervertebral disc degeneration in sheep models.” Veterinary Radiology & Ultrasound. September (2021). 62(5):568-572.
  9. Borem, R., Walters, J., Madeline, A., Madeline, L., Gill, S., Easley, J. Mercuri, J. “Characterization of chondroitinase-induced lumbar intervertebral disc degeneration in a sheep model intended for assessing biomaterials.” Journal of Biomedical Materials Research – Part A. July (2021). 109(7):1232-1246.
  10. Smith, K., Mercuri, J. “Microgravity and radiation effects on astronaut intervertebral disc health.” Aerospace Medicine and Human Performance. May (2021). 92(5):342-352.
  11. Chen, X., Li, Y., Wyman, N., Zhang, Z., Fan, H., Le, M., Gannon, S., Rose, C., Zhang, Z., Mercuri, J., Yao, H., Gao, B., Woolf, S., Pecot, T., Ye, T. "Deep Learning Provides High Accuracy in Automated Chondrocyte Viability Assessment in Articular Cartilage Using Nonlinear Optical Microscopy.” Biomedical Optics Express. April (2021). 12(5):2759-2772.
  12. Wiegand. M., Khullar, P.,Mercuri, J. , Gilbert, J. Synthetic periprosthetic synovial fluid development for in vitro cell-tribocorrosion testing using the Taguchi array approach." Journal of Biomedical Materials Research – Part A.(2021). 109(4):551-561.
  13. Li, Y., Watkins, B., Saini, N., Gannon, S., Nadeau, E., Reeves, R., Gao, Z., Pellegrini, V., Yao, H., Mercuri, J., Ye, T. “Nonlabeling and quantitative assessment of chondrocyte viability in articular cartilage with intrinsic nonlinear optical signatures.” Experimental Biology and Medicine. Feb (2020). 245(4):348-359.
  14. Borem, R., Madeline, A., Bowman, M., Gill, S., Tokish, J., Mercuri, J. “Differential effector response of amnion- and adipose-derived mesenchymal stem cells to inflammation; Implications for intradiscal therapy.” Journal of Orthopaedic Research. Nov (2019) 37;11. 2445-2456.
  15. Borem, R., Madeline, A., Vela Jr., R., Gill, S., Mercuri, J. “Multi-laminate annulus fibrosus repair scaffold with an interlamellar matrix enhances impact resistance, prevents herniation and assists in restoring spinal kinematics.” Journal of Mechanical Behavior of Biomedical Materials. (Apr. 2019) 1;95. 41-52.
  16. Walters, J., Gill, S., Mercuri, J. “Ethanol-mediated compaction and crosslinking enhance mechanical properties and degradation resistance while maintaining cytocompatibility of a nucleus pulposus scaffold.” Journal of Biomedical Materials Research – Part A. Feb. (2019). 107(8): 2488-2499.
  17. Marionneaux, A., Walters, J., Guo, H. Mercuri, J. “Tailoring the subchondral bone phase of a multi-layered osteochondral implant to support enhanced bone healing and a cartilage analog.” Acta Biomaterialia. Sep (2018). 15(78):351-364.
  18. Hensley, A., Rames, J., Casler, V., Rood, C., Walters, J., Fernandez, C., Gill, S., Mercuri, J. “Decellularization and characterization of a whole intervertebral disc xenograft scaffold.” Journal of Biomedical Materials Research – Part A. Sep (2018). 106(9): 2412-2423.
  19. Topoluk, N., Steckbeck, K., Siatkowski, S., Burnikel, B., Tokish, J., Mercuri, J. “Amniotic mesenchymal stem cells mitigate osteoarthritis progression in a synovial macrophage-mediated in vitro explant co-culture model.” Journal of Tissue Engineering and Regenerative Medicine. (2018); 12 (4), 1097-1110.
  20. Borem, R., Madeline, A., Walters, J., Mayo, H., Gill, S., Mercuri, J. "Angle-ply biomaterial scaffold for annulus fibrosus repair replicates native tissue mechanical properties, restores spinal kinematics, and supports cell viability." Acta Biomaterialia. (2017); 58, 254-268.
  21. Topoluk, N., Hawkins, R., Tokish, J., Mercuri, J. “Amniotic Mesenchymal Stromal Cells Exhibit Preferential Osteogenic and Chondrogenic Differentiation and Enhanced Matrix Production Compared with Adipose Mesenchymal Stromal Cells.” The American Journal of Sports Medicine (2017); 45 (11), 2637-2646.
  22. Fernandez, C., Marionneaux, A., Gill, S., Mercuri, J. “Biomimetic Nucleus Pulposus Scaffold Created from Bovine Caudal Intervertebral Discs Utilizing an Optimal Decellularization Procedure.” Journal of Biomedical Materials Research – Part A. (2016): 104(12), 3093-3106.
  23. McGuire, R., Borem, R., Mercuri, J. “The fabrication and characterization of a multi-laminate, angle-ply collagen patch for annulus fibrosus repair.” Journal of Tissue Engineering and Regenerative Medicine. (2017); 11(12), 3488-3493.
  24. Keeley, R., Topoluk, N., Mercuri, J., “Tissues Reborn: Fetal membrane-derived matrices and stem cells in orthopedic regenerative medicine.” Critical Reviews in Biomedical Engineering. (2014); 42(3-4), 249-70.
  25. Mercuri, J., Addington, C., Pascal, R., Gill, S., Simionescu, D.  . “Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration.” Journal of Biomedical Materials Research – Part A. Feb. (2014); 102 (12), 4380-93.
  26. Mercuri, J., Patnaik, S., Gill, S., Liao, J., Simionescu, D. "Regenerative Potential of Decellularized Porcine Nucleus Pulposus Hydrogel Scaffolds; Stem Cell Differentiation, Matrix Remodeling and Biocompatibility Studies". Tissue Engineering – Part A. Apr (2013); 19, 952-66. 23140227
  27.  Mercuri, J., Gill, S., Simionescu, D. “Novel Tissue Derived Biomimetic Scaffold for Regenerating the Human Nucleus Pulposus.” Journal of Biomedical Materials Research – Part A. Feb (2011); 96A, 422-435. 21171162
  28. Xu, J., Mercuri, J., Zhang, Z., Xu, F.  “Psychological, social, and behavioral factors that influence drug efficacy: a noteworthy research subject in clinical pharmacology.” British Journal of Clinical Pharmacology. (2008); 66, 901-2. 18823301
  29.  Mercuri, J., Lovekamp, J., Simionescu, D., Vyavahare, N.  "Glycosaminoglycan-targeted Fixation for Improved Bioprosthetic Heart Valve Stabilization." Biomaterials. (2007); 28, 496-503. 17030363
  30. Lovekamp, J., Simionescu, D., Mercuri, J., Zubiate, B., Sacks, M., Vyavahare, N.  “Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves.” Biomaterials. (2005); 27, 1507-1518. 16144707

Conference Proceedings

  1.  Theos, C., Mercuri, J., “Development of a pre-crosslinked decellularized extracellular matrix-based scaffold for nucleus pulposus replacement.” Society for Biomaterials Annual Meeting, San Diego, CA. April 2023. 
  2.  Thomas, V., Mercuri, J. “A potential extracellular matrix-based scaffold for cartilage regeneration.” Society for Biomaterials Annual Meeting, San Diego, CA. April 2023.
  3.  Vera Martinez, A., Reza, A., Mercuri, J. “Evaluating the osteoinductivity of different biomaterials for bone regeneration.” Society for Biomaterials Annual Meeting, San Diego, CA. April 2023.
  4.  DiNicola, E., Mercuri, J. “Cigarette smoke extract decreases viable chondrocytes in cartilage explants.” Orthopaedic Research Society Meeting, Dallas TX. February 2023.
  5. Krussig, M., Namiranian, M., Mercuri, J. “Hyaluronic acid and human amniotic mesenchymal stem cells show therapeutic effect on post-traumatic osteoarthritis in a rodent model.” Orthopaedic Research Society Meeting, Dallas TX. February 2023. 
  6. Cannon, K., Gill, S., Mercuri, J. “Mesenchymal stem cell survival in intervertebral disc-like pH is cell source dependent.” Orthopaedic Research Society Meeting, Dallas TX. February 2023.
  7.  Miller, B., Cannon, K., Gill, S., Richardson, W., Mercuri, J. “Mesenchymal stem cell survival and activity in low pH and tensile strain is dependent on cell source.” Orthopaedic Research Society Meeting, Dallas TX. February 2023. 
  8.  Thomas, V., Buchweitz, N., Wu, Y., Mercuri, J. “The Mechanical Characterization of a Novel Cartilage Repair Scaffold.” Society for Biomaterials Annual Meeting. Baltimore, MD. April 2022. 
  9. Namiranian, M., Smith, K., Mercuri, J. “Initial characterization of a 3D organoid model for studying the effects of space on intervertebral disc health.” American Society for Gravitational and Space Research Annual Meeting. Baltimore, MD. November 2021.
  10. Krussig, M., Theos, C., Gill, S., Mercuri, J. “Bovine intervertebral disc organ culture model for assessing regenerative therapeutics for herniation repair.” North American Spine Society Annual Meeting. Boston, MA. October 2021.
  11. Pill, S., Tokish, J., Ahearn, B., Adams, K., Hutchinson, J., Hall, T., Siffri, P., Burnikel, B., Cassas, K., Wyland, D., Mercuri, J., Kissenberth, M., “Amniotic tissue preserves pain relief and function compared to steroid in severe knee osteoarthritis: A double-blind, randomized Prospective Study.” 38th annual meeting of the Southern Orthopaedic Association, July 2021.
  12. Mercuri, J. “Development of biomimetic extracellular matrix-based scaffolds for intervertebral disc repair.” Institute of Biological Engineering Virtual Meeting, April 2021.
  13. Vera Martinez, A., Mercuri, J. “Improving the porosity of the subchondral bone phase of a multi-layered osteochondral biomaterial.” Society for Biomaterials Virtual Meeting, April 2021.
  14. Smith, K., Mercuri, J. “Incorporation of extracellular matrix derived biomaterials into an intervertebral disc organoid model.” Society for Biomaterials Virtual Meeting, April 2021.
  15. Krussig, M., Theos, C., Walters, J., Mercuri, J. “Development of a bovine intervertebral disc herniation organ culture model to evaluate regenerative biomaterials.” Society for Biomaterials Virtual Meeting, April 2021.
  16. Thomas, V., Marionneaux, A., Mercuri, J. “The biochemical and mechanical modification of a novel scaffold to treat focal cartilage defects.” Society for Biomaterials Virtual Meeting, April 2021.
  17. Harbold, A., Hamilton, G., Harrison, C., Jones, J., Mercuri, J., Bridges, W. Horos Open-source Image Analysis Software Yields Repeatable MRI Measures of Lumbar Intervertebral Disc Degeneration in Sheep Models. Biomedical Engineering Society 2020 Virtual Meeting. October. 2020.
  18. Meyerink, J., Wood, S., Mercuri, J., Anderson, R., Scott, B., Crawford, G. “Application of titanium dioxide nanotubes and lattice light-sheet microscopy in establishing early-stage cellular response mechanisms.” The Minerals, Metals & Materials Society Meeting, San Diego, CA, Feb 2020.
  19. Smith, K., Walters, J., Mercuri, J. “Towards the development of an intervertebral disc organoid culture model to study the effects of microgravity and radiation exposure.” The American Society for Gravitational and Space Research 2019 Annual Conference, Denver, CO, Nov 2019.
  20. Casler, V., Garon, A., Krussig, M., Namiranian, M., Walters, J., Mercuri, J. “Mechanical compression improves decellularization of intact intervertebral disc xenografts.” Society for Biomaterials Meeting, Seattle, WA, April 2019.
  21. Garon, A., Borem, R., Walters, J., Mercuri, J. “Compaction and crosslinking of nucleus pulposus replacement improves repair efficacy in a spinal kinematic model.” Society for Biomaterials Meeting, Seattle, WA, April 2019 (accepted).
  22. Dunton, C., Smith, K., Garland, J., Mercuri , J., Nagatomi, J. “Differential response of nucleus pulposus and annulus fibrosus cells exposed to hydrostatic pressure.” Orthopaedic Research Society Meeting, Austin, TX, February 2019. (submitted).
  23. Bowman, M., Mercuri, J . “Comparing the therapeutic efficacy of amniotic membrane- and adipose-derived stem cells to mitigate osteoarthritis progression in the Dunkin Hartley guinea pig. Orthopaedic Research Society Meeting, Austin, TX, February 2019. (submitted).
  24. Borem, R., Madeline, A., Vela, R., Gill, S., Mercuri, J. “Intervertebral disc repair patch emulates native biaxial mechanics and supports cell-mediated tissue regeneration.” Biomedical Engineering Society Meeting, Atlanta, GA, October 2018.
  25. Borem, R., Gill, S., Mercuri, J. “Biomimetic annular implant for intervertebral disc tissue engineering.” National Idea Symposium of Biomedical Research Excellence, Washington, DC, June 2018.
  26. Borem, R., Walters, J., Madeline, L., Gill, S., Mercuri, J. “Development of a large animal model of functional intervertebral disc degeneration.” National Idea Symposium of Biomedical Research Excellence, Washington, DC, June 2018.
  27. Borem, R., Walters, J., Gill, S., Mercuri, J. “Mechanically competent biologic implants for the repair and regeneration of intervertebral discs.” Southeastern Medical Device Association Conference, Greenville, SC, May 2018.
  28. Marionneaux, A., Mercuri, J. “One-step, off-the-shelf construct for the repair of focal osteochondral defects.” Southeastern Medical Device Association Conference, Greenville, SC, May 2018.
  29. Borem, R., Walters, J., Madeline, A., Vela, R., Gill, S., Mercuri, J. “Multi-laminate, angle-ply annulus fibrosus repair implant injected with glycosaminoglycan gel demonstrates increased biaxial impact burst strength and restores spinal kinematics.” Society for Biomaterials Meeting, Atlanta, GA, April 2018.
  30. Borem, R., Walters, J., Madeline, A., Madeline, L., Gill, S., Mercuri, J. “Stem cell seeded biomimetic nucleus pulposus and annulus fibrosus implants promote living repair of degenerative intervertebral discs in sheep.” Society for Biomaterials Meeting, Atlanta, GA, April 2018.
  31. Borem, R., Madeline, A., Vela, R., Gill, S., Mercuri, J. “Multi-laminate, angle-ply annulus fibrosus implant supports tissue regeneration for intervertebral disc repair.” Annual Regenerative Medicine Workshop, Charleston, SC, March 2018.
  32. Borem, R., Bowman, M., Madeline, A., Mercuri, J. “MSC differentiation in inflammation depends on cell origin – implications for orthopaedic regenerative medicine.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  33. Borem, R., Walters, J., Madeline, A., Madeline, L., Mercuri, J. “Characterization of a chemonucleolysis-induced ovine model of intervertebral disc degeneration – A pilot study.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  34. Borem, R., Madeline, A., Vela, R., Mercuri, J. “Characterization of the biaxial mechanical properties of native bovine annulus fibrosus tissue in comparison with a multi-laminate angle-ply patch implant for annulus fibrosus repair.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  35. Walters, J., Mercuri, J. “Ethanol-mediated compaction and crosslinking enhance mechanical properties of a biomimetic nucleus pulposus replacement.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  36. Marionneaux, A., Mercuri, J. “Mechanical characterization of a novel osteochondral tissue implant.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  37. Casler, V., Rood, C., Mercuri, J. “Histological and mechanical characterization of a decellularized intact intervertebral disc xenograft.” Orthopaedic Research Society Meeting, New Orleans, LA, March 2018.
  38. Routhier, K., Mercuri, J. “Differential response of amnion and adipose MSCs to low grade inflammation – implications for mitigating osteoarthritis.” Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) Annual Conference, Charlotte, NC, December 2017. Tissue Eng. – Part A. Dec (2017). 23(S1): S-1-S-159.
  39. Fernandez, C., Mercuri, J. “Amnion MSCs remodel biomimetic nucleus pulposus replacement for intervertebral disc regeneration.” Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) Annual Conference, Charlotte, NC, December 2017. Tissue Eng. – Part A. Dec (2017). 23(S1): S-1-S-159.
  40. Borem, R., Madeline, A., Mayo, H., Mercuri, J. “Crosslinked Angle-Ply Annulus Fibrosus Repair Patch Resists Enzymatic Degradation While Maintaining Mechanical Properties and Cell Viability.” Orthopaedic Research Society Meeting, San Diego, CA, March March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  41. Borem, R., Walters, J., Madeline, A., Gill, S., Mercuri, J. “Partially Restored Kinematics of Spinal Units Following the Repair with Novel Annulus Fibrosus and Nucleus Pulposus Biomaterials.” Orthopaedic Research Society Meeting, San Diego, CA, March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  42. Marionneaux, A., Mercuri, J. “Tailoring the Subchondral Bone Phase of a Multi-Phase Osteochondral Repair Construct for Enhanced Bone Healing.” Orthopaedic Research Society Meeting, San Diego, CA, March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  43. Topoluk, N., Tokish, J., Mercuri, J. “Amniotic mesenchymal stem cells attenuate osteoarthritis progression in vivo more effectively than adipose stem cells.” Orthopaedic Research Society Meeting, San Diego, CA, March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  44. Steckbeck, K., Burnikel, B., Mercuri, J. “A single dose of autologous protein solution exhibits potential to mitigate osteoarthritis via a chondroprotective effect.” Orthopaedic Research Society Meeting, San Diego, CA, March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  45. Hensley, A., Rames, J., Compton, C., Litzinger, T., Watt, T., Wood, S., Aggarwal, A., Williams, K., Fernandez, C., Mercuri, J. “Intact composite intervertebral disc scaffolds developed by decellularizing bovine tail caudal discs.” Orthopaedic Research Society Meeting, San Diego, CA, March 2017. J Orthop Res. Mar (2017). 35(S1): s1.
  46. Fernandez, C., Gill, S., Mercuri, J. “Acellular nucleus pulposus scaffold for NP replacement.” Southeastern Medical Device Association Conference, Nashville, TN, May 2016.
  47. Marionneaux, A., Marrocco, A., Freeman, N., Seignious, G., Stokes, M., Santillo, A., Mercuri, J. “Conventus – A novel orthopaedic drill guide docking system.” Southeastern Medical Device Association Conference, Nashville, TN, May 2016.
  48. Borem, R., McGuire, R., Madeline, A., Gill, S., Mercuri, J. “Multi-laminate AF patch for annulus fibrosus Repair.” Southeastern Medical Device Association Conference, Nashville, TN, May 2016.
  49. Topoluk, N., Siatkowski, S., Burnikel, B., Tokish, J., Mercuri, J. “The targeted depletion of synovial macrophages in an in vitro OA tissue explant co-culture model improves chondrocyte viability and mitigates cartilage destruction.” Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  50. Topoluk, N., Burnikel, B., Tokish, J., Mercuri, J. “Human perinatal stem cells mitigate osteoarthritis progression more effectively than adult stem cells.” Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  51. Topoluk, N., Steckbeck, K., Siatkowski, S., Burnikel, B., Tokish, J., Mercuri, J. “Evaluating the effect of direct and indirect contact co-culture of human amniotic stem cells in osteoarthritic joint tissue explants – implications for therapeutic administration.” Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  52. Topoluk, N., Steckbeck, K., Burnikel, B., Tokish, J., Mercuri, J. “Validation of an in vitro co-culture model comprised of osteoarthritic joint tissue explants.” Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  53. Borem, R., Gill, S., Mercuri, J. “Mechanical characterization of a multi-laminate, angle-ply collagen patch for annulus fibrosus repair. Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  54. Welch, A., Siatkowski, S., Kissenberth, M., Tolan, S., Hawkins, R., Tokish, J., Colbath, G., Mercuri, J. “In search of an ideal cell delivery vehicle for biologically augmenting massive rotator cuff repairs.” Orthopaedic Research Society Meeting, Orlando, FL, March 2016.
  55. Tabbaa, S., Borem, R., Marionneaux, A., Mercuri, J. Business Plan Competition: “Vitality Orthopaedics – Keeping people active longer.” Tissue Engineering and Regenerative Medicine International Society (TERMIS) – World Congress Conference; Boston, MA, September 2015.
  56. Topoluk, N., Steckbeck, K., Burnikel, B., Tokish, J., Mercuri, J. “The potential of human amniotic stem cells to mitigate osteoarthritis progression.” Tissue Engineering and Regenerative Medicine International Society (TERMIS) – World Congress Conference; Boston, MA, September 2015.
  57. Fernandez, C., Gill, S., Mercuri, J. “Decellularized bovine nucleus pulposus as a biomimetic scaffold for intervertebral disc regeneration.” Tissue Engineering and Regenerative Medicine International Society (TERMIS) – World Congress Conference; Boston, MA, September 2015.
  58. Marionneaux, A., Stokes, M., Seignious, G., Santillo, A., Mercuri, J. “Conventus – A novel orthopaedic drill guide docking system.” Southeastern Medical Device Association Conference, Atlanta, GA, April 2015.
  59. Siatkowski, S., Pate, T., Hawkins, R., Kissenberth, M., Tolan, S., Colbath, G., Mercuri, J. “Biceps Tendon Tenocytes from Patients Undergoing Rotator Cuff Repair Induce Adipose Derived Stem Cell Differentiation – Towards Tendon Engineering in the Operating Room.” Orthopaedic Research Society Meeting, LasVegas, NV, March 2015.
  60. Topoluk, N., Keeley, R., Mercuri, J. “Comparative analysis of human amnion and adipose derived stem cells for regenerating orthopaedic tissues.” Orthopaedic Research Society Meeting, LasVegas, NV, March 2015.
  61. McGuire, R., Gill, S., Simionescu, D., Mercuri, J. “Decellularized pericardium as a biological patch for annulus fibrosus repair.” Orthopaedic Research Society Meeting, LasVegas, NV, March 2015.
  62. Colbath, G., Dion, G., Mercuri, J., Simionescu, D., Schlegel, T., Hawkins, R. “Scaffold Augmentation with Adipose Stem Cell – Derived Tenocytes Improves Tendon Remodeling.” The American Academy of Orthopaedic Surgeons Annual Meeting, New Orleans, LA, March 2014.
  63. Grace Margaret Dion, Jeremy Mercuri, Dan Simionescu, Richard Hawkins. “Evaluation of BMP-12 to Induce Differentiation of Adipose Derived Stem Cells Into Tenocytes to Improve Rotator Cuff Repair.” Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, Oct 24-27, 2012.
  64. Mercuri, J., Patnaik, S., Gill, S., Liao, J., Simionescu, D. “Assessment of Human Stem Cell Differentiation on a Biomimetic Scaffold for Nucleus Pulposus Tissue Engineering.” Tissue Engineering and Regenerative Medicine International Society (TERMIS) – North American Annual Conference; December 2011.
  65. Mercuri, J., Addington, C., Gill, S., Simionescu, D. “New Hydrogel Biomaterials for the Minimally Invasive Treatment of Disc Degeneration.” The Spine Study Group 22nd Symposium; May 2011.
  66. Addington, C., Mercuri, J., Gill, S., Simionescu, D. “Stabilized Elastin-Glycosaminoglycan-Collagen Shape-Memory Sponge Scaffolds for Nucleus Pulposus Tissue Engineering”. Orthopedic Research Society Meeting, Long Beach, CA, January 2011.
  67. Mercuri, J., Gill, S., Simionescu, D. “Xenogenic cues for human mesenchymal stem cell differentiation towards a Nucleus Pulposus cell-like phenotype”, North American Spine Society Orlando, FL, 2010.
  68. Mercuri, J., Addington, C., Gill, S., Simionescu, D. “New hydrogel biomaterials for the minimally invasive treatment of disc degeneration”. Annual Meeting of the Society for Minimally Invasive Spine Surgery, Miami, FL, 2010.
  69. Mercuri, J., Pascal, R., Gill, S., Simionescu, D. "Tissue-Derived Extracellular Matrix Scaffolds for Regenerating the Human Nucleus Pulposus”, Orthopedic Research Society Meeting, New Orleans, LA, 2010.
  70. Mercuri. J, Gill, S, Simionescu, D. “Novel penta-galloyl-glucose Stabilized Hydrogels for Tissue Engineering the Nucleus Pulposus”. Orthopaedic Research Society, Las Vegas, 2009.
  71. Simionescu, A., Albers, C., Stowers, R., Sierad, L., Mercuri, J., Chuang, T., Tedder, M., Simionescu D. “Penta-galloylglucose-Stabilized Acellular Scaffolds for Tissue Engineered Heart Valves”. Tissue Engineering and Regenerative Medicine Society (TERMIS)-North America Annual Conference, San Diego, CA, December 7 - 10, 2008.
  72. Mercuri, J., Isenburg, J., Simionescu, D., Vyavahare, N. “Comparison of Glycosaminoglycan-Targeted Fixation Chemistries and their Effects on Bioprosthetic Heart Valve Cuspal Tissue.” Society for Biomaterials 2006 Annual Meeting; April 2006.
  73. Mercuri, J., Shah, S., Isenburg, J., Simionescu, D., Vyavahare, N. “Glycosaminoglycan Stabilization in Bioprosthetic Heart Valve Leaflets.” 10th Annual Hilton Head Workshop and 2nd Biennial Heart Valve Meeting; March 2006.
  74. Mercuri, J., Sangkavasi, B., Stehman, C., Kowall, J., Dore, L., Lowman, A., Marcolongo, M. “The Development of a Novel Injectable Hydrogel for the Replacement of the Nucleus Pulposus Region of the Intervertebral Disc.” Drexel University Fifth Annual Research Day; April 2003.

Scholarly Publications

  1. Mercuri, J., Simionescu D. “Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration”. By invitation. Review paper accepted for publication in Advances in Polymer Sciences, (Springer Berlin/Heidelberg), special volume on Polymers in Nanomedicine. Editor is Professor Kunugi, Kyoto, Japan, Dec. (2010).

Patents

  1. Patent Application (PCT): “Annulus repair devices, systems and methods.” Filed 10/07/2022 – Application No. PCT/US22/46064.
  2. Patent Application (US): “Annulus repair devices, systems and methods.” Filed 10/07/2022 – Application No. 17/962,046.
  3. Issued Patent (PCT): “Multi-layered biomimetic material and method of formation.” Date of Issuance: 12/15/2021 – Patent No. EP 3 347 062.
  4. Issued Patent (US): “Positioning bracket for multiple bone tunnel drill guide.” Date of Issuance: 12/22/2020 – Patent No. 10,869,680.
  5. Issued Patent (US): “Multi-layered biomimetic material and method of formation.” Date of Issuance: 6/30/2020 – Patent No. 10,695,463 B2.
  6. Issued Patent (US): “Decellularized biomaterial and method for formation.” Date of Issuance: 6/9/2020 – Patent No. 10,675,381.
  7. Patent Application (US): “Decellularized Biomaterial and Method for Formation.” Filed 04/15/2020 – Application No. 16/849,326.
  8. Patent Application (US): “Multi-Layered Osteochondral Construct and Subchondral Bone Analog Thereof.” Filed 03/05/2019 – Application No. 16/292,386
  9. Issued Patent (US): “Bioactive Flowable Wash-Out Resistant Bone Graft Substitute and Method for Production Thereof.” Date of Issuance: 2/5/2019 – Patent No. 10,195,305.
  10. Provisional Patent Application (US): “Tailoring the subchondral bone phase of a multi-phase osteochondral implant to support bone healing and a cartilage analog.” Filed 03/05/2018 – Application No. 62/638,422
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