The Vyavahare Lab

Publications

Selected Publications

  1. Dhital, S., & Vyavahare, N. R. (2020). Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice. Plos one, 15(3), e0227165.
  2. Lane, B. A., Wang, X. I. A. O. Y. I. N. G., Lessner, S. M., Vyavahare, N. R., & Eberth, J. F. (2020). Targeted Gold Nanoparticles as an Indicator of Mechanical Damage in an Elastase Model of Aortic Aneurysm. Annals of biomedical engineering. 48(8),2268-2278.
  3. Karamched, S. R., Nosoudi, N., Moreland, H. E., Chowdhury, A., & Vyavahare, N. R. (2019). Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease. Scientific reports, 9(1), 1-11.
  4. Wang, X., Lane, B. A., Eberth, J. F., Lessner, S. M., & Vyavahare, N. R. (2019). Gold nanoparticles that target degraded elastin improve imaging and rupture prediction in an AngII mediated mouse model of abdominal aortic aneurysm. Theranostics, 9(14), 4156.
  5. Parasaram, V., Nosoudi, N., Chowdhury, A., & Vyavahare, N. (2018). Pentagalloyl glucose increases elastin deposition, decreases reactive oxygen species and matrix metalloproteinase activity in pulmonary fibroblasts under inflammatory conditions. Biochemical and biophysical research communications, 499(1), 24-29.
  6. Vyavahare, N., & Tam, H. (2018). Bioprosthetic Heart Valves: From a Biomaterials Perspective. In Advances in Heart Valve Biomechanics (pp. 337-382). Springer, Cham.
  7. Tam, H., Zhang, W., Infante, D., Parchment, N., Sacks, M., & Vyavahare, N. (2017). Fixation of bovine pericardium-based tissue biomaterial with irreversible chemistry improves biochemical and biomechanical properties. Journal of cardiovascular translational research, 10(2), 194-205.
  8. Parasaram, V., Nosoudi, N., LeClair, R. J., Binks, A., & Vyavahare, N. (2016). Targeted drug delivery to emphysematous lungs: Inhibition of MMPs by doxycycline loaded nanoparticles. Pulmonary Pharmacology & Therapeutics, 39, 64.
  9. Nosoudi, N., Chowdhury, A., Siclari, S., Karamched, S., Parasaram, V., Parrish, J., ... & Vyavahare, N. (2016). Reversal of vascular calcification and aneurysms in a rat model using dual targeted therapy with EDTA-and PGG-loaded nanoparticles. Theranostics, 6(11), 1975.
  10. Nosoudi, N., Chowdhury, A., Siclari, S., Parasaram, V., Karamched, S., & Vyavahare, N. (2016). Systemic delivery of nanoparticles loaded with pentagalloyl glucose protects elastic lamina and prevents abdominal aortic aneurysm in rats. Journal of cardiovascular translational research, 9(5-6), 445-455.
  11. Nosoudi, N., Nahar-Gohad, P., Sinha, A., Chowdhury, A., Gerard, P., Carsten, C. G., ... & Vyavahare, N. R. (2015). Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles. Circulation research, 117(11), e80-e89.
  12. Nahar-Gohad, P., Gohad, N., Tsai, C. C., Bordia, R., & Vyavahare, N. (2015).Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP-2–SMAD-5 pathway. Calcified tissue international, 96(4), 359-369.
  13. Simmers, P., Gishto, A., Vyavahare, N., & Kothapalli, C. R. (2015). Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue Engineering Part A, 21(7-8), 1455-1470.
  14. Lei, Y., Sinha, A., Nosoudi, N., Grover, A., & Vyavahare, N. (2014). Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells. Experimental cell research, 323(1), 198-208.
  15. Sinha, A., Shaporev, A., Nosoudi, N., Lei, Y., Vertegel, A., Lessner, S., & Vyavahare, N. (2014). Nanoparticle targeting to diseased vasculature for imaging and therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 10(5), e1003-e1012.
  16. Tripi, D. R., & Vyavahare, N. R. (2014). Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves. Journal of biomaterials applications, 28(5), 757-766.
  17. Sinha, A., Nosoudi, N., & Vyavahare, N. (2014). Elasto-regenerative properties of polyphenols. Biochemical and biophysical research communications, 444(2), 205-211.
  18. Lei, Y., Nosoudi, N., & Vyavahare, N. (2014). Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release, 196, 79-86.
  19. Eckert, C. E., Fan, R., Mikulis, B., Barron, M., Carruthers, C. A., Friebe, V. M., ... & Sacks, M. S. (2013). On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet. Acta biomaterialia, 9(1), 4653-4660.
  20. Sinha, A., & Vyavahare, N. R. (2013). High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells. Diabetes and Vascular Disease Research, 10(5), 410-419.
  21. Lei, Y., Grover, A., Sinha, A., & Vyavahare, N. (2013). Efficacy of reversal of aortic calcification by chelating agents. Calcified tissue international, 93(5), 426-435.
  22. Leong, J., Munnelly, A., Liberio, B., Cochrane, L., & Vyavahare, N. (2013). Neomycin and carbodiimide crosslinking as an alternative to glutaraldehyde for enhanced durability of bioprosthetic heart valves. Journal of biomaterials applications, 27(8), 948-960.
  23. Shanmugam, I., Sinha, A., Norris, R. A., Markwald, R., & Vyavahare, N. (2013). Periostin as an early marker for elastin mediated vascular smooth muscle cell calcification. Cardiovascular System, 1, 2.
  24. Munnelly, A. E., Cochrane, L., Leong, J., & Vyavahare, N. R. (2012). Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves. Biomaterials, 33(1), 1-8.
  25. Munnelly, A., Schoen, F., & Vyavahare, N. (2012). Biomaterial calcification: Mechanisms and prevention. In Degradation of Implant Materials (pp. 359-392). Springer, New York, NY.
  26. Friebe, V. M., Mikulis, B., Kole, S., Ruffing, C. S., Sacks, M. S., & Vyavahare, N. R. (2011). Neomycin enhances extracellular matrix stability of glutaraldehyde crosslinked bioprosthetic heart valves. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 99(2), 217-229.
  27. Kurane, A., & Vyavahare, N. (2009). In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. Journal of tissue engineering and regenerative medicine, 3(4), 280-289.
  28. Raghavan, D., Starcher, B. C., & Vyavahare, N. R. (2009). Neomycin binding preserves extracellular matrix in bioprosthetic heart valves during in vitro cyclic fatigue and storage. Acta biomaterialia, 5(4), 983-992.
  29. Zhang, C., Wen, X., Vyavahare, N. R., & Boland, T. (2008). Synthesis and characterization of biodegradable elastomeric polyurethane scaffolds fabricated by the inkjet technique. Biomaterials, 29(28), 3781-3791.
  30. Shah, S. R., & Vyavahare, N. R. (2008). The effect of glycosaminoglycan stabilization on tissue buckling in bioprosthetic heart valves. Biomaterials, 29(11), 1645-1653.
  31. Kutty, J. K., Cho, E., Lee, J. S., Vyavahare, N. R., & Webb, K. (2007). The effect of hyaluronic acid incorporation on fibroblast spreading and proliferation within PEG-diacrylate based semi-interpenetrating networks. Biomaterials, 28(33), 4928-4938.
  32. Raghavan, D., Simionescu, D. T., & Vyavahare, N. R. (2007). Neomycin prevents enzyme-mediated glycosaminoglycan degradation in bioprosthetic heart valves. Biomaterials, 28(18), 2861-2868.
  33. Simionescu, D. T., & Vyavahare, N. (2007). U.S. Patent No. 7,189,259. Washington, DC: U.S. Patent and Trademark Office.
  34. Isenburg, J. C., Simionescu, D. T., Starcher, B. C., & Vyavahare, N. R. (2007). Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation, 115(13), 1729-1737.
  35. Simionescu, A., Simionescu, D. T., & Vyavahare, N. R. (2007). Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-β1: role of myofibroblasts in vascular calcification. The American journal of pathology, 171(1), 116-123.
  36. Kurane, A., Simionescu, D. T., & Vyavahare, N. R. (2007). In vivo cellular repopulation of tubular elastin scaffolds mediated by basic fibroblast growth factor. Biomaterials, 28(18), 2830-2838.
  37. Simpson, C. L., Lindley, S., Eisenberg, C., Basalyga, D. M., Starcher, B. C., Simionescu, D. T., & Vyavahare, N. R. (2007). Toward cell therapy for vascular calcification: osteoclast-mediated demineralization of calcified elastin. Cardiovascular Pathology, 16(1), 29-37.
  38. Mercuri, J. J., Lovekamp, J. J., Simionescu, D. T., & Vyavahare, N. R. (2007). Glycosaminoglycan-targeted fixation for improved bioprosthetic heart valve stabilization. Biomaterials, 28(3), 496-503.
  39. Vyavahare, N. R., Isenburg, J. C., & Simionescu, D. T. (2007). U.S. Patent No. 7,252,834. Washington, DC: U.S. Patent and Trademark Office.
  40. Simionescu, D. T., Lu, Q., Song, Y., Lee, J., Rosenbalm, T. N., Kelley, C., & Vyavahare, N. R. (2006). Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds. Biomaterials, 27(5), 702-713.
  41. Lovekamp, J. J., Simionescu, D. T., Mercuri, J. J., Zubiate, B., Sacks, M. S., & Vyavahare, N. R. (2006). Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves. Biomaterials, 27(8), 1507-1518.
  42. Isenburg, J. C., Karamchandani, N. V., Simionescu, D. T., & Vyavahare, N. R. (2006). Structural requirements for stabilization of vascular elastin by polyphenolic tannins. Biomaterials, 27(19), 3645-3651.
  43. Lee, J. S., Basalyga, D. M., Simionescu, A., Isenburg, J. C., Simionescu, D. T., & Vyavahare, N. R. (2006). Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. The American journal of pathology, 168(2), 490-498.
  44. Isenburg, J. C., Simionescu, D. T., & Vyavahare, N. R. (2005). Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall. Biomaterials, 26(11), 1237-1245.
  45. Lu, Q., Simionescu, A., & Vyavahare, N. (2005). Novel capillary channel fiber scaffolds for guided tissue engineering. Acta biomaterialia, 1(6), 607-614.
  46. Simionescu, A., Philips, K., & Vyavahare, N. (2005). Elastin-derived peptides and TGF-β1 induce osteogenic responses in smooth muscle cells. Biochemical and biophysical research communications, 334(2), 524-532.
  47. Connolly, J. M., Alferiev, I., Eidelman, N., Sacks, M., Palmatory, E., Kronsteiner, A., ... & Vyavahare, N. (2005).Triglycidylamine crosslinking of porcine aortic valve cusps or bovine pericardium results in improved biocompatibility, biomechanics, and calcification resistance: chemical and biological mechanisms. The American journal of pathology, 166(1), 1-13.
  48. Isenburg, J. C., Simionescu, D. T., & Vyavahare, N. R. (2004). Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid. Biomaterials, 25(16), 3293-3302.
  49. Sun, W., Sacks, M., Fulchiero, G., Lovekamp, J., Vyavahare, N., & Scott, M. (2004). Response of heterograft heart valve biomaterials to moderate cyclic loading. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 69(4), 658-669.
  50. Basalyga, D. M., Simionescu, D. T., Xiong, W., Baxter, B. T., Starcher, B. C., & Vyavahare, N. R. (2004). Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation, 110(22), 3480-3487.
  51. Lu, Q., Ganesan, K., Simionescu, D. T., & Vyavahare, N. R. (2004). Novel porous aortic elastin and collagen scaffolds for tissue engineering. Biomaterials, 25(22), 5227-5237.
  52. Bailey, M., Pillarisetti, S., Jones, P., Xiao, H., Simionescu, D., & Vyavahare, N. (2004). Involvement of matrix metalloproteinases and tenascin-C in elastin calcification. Cardiovascular Pathology, 13(3), 146-155.
  53. Bailey, M. T., Pillarisetti, S., Xiao, H., & Vyavahare, N. R. (2003). Role of elastin in pathologic calcification of xenograft heart valves. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 66(1), 93-102.
  54. Simionescu, D. T., Lovekamp, J. J., & Vyavahare, N. R. (2003). Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 66(4), 755-763.
  55. Simionescu, D. T., Lovekamp, J. J., & Vyavahare, N. R. (2003). Glycosaminoglycan-degrading enzymes in porcine aortic heart valves: implications for bioprosthetic heart valve degeneration. Journal of Heart Valve Disease, 12(2), 217-225.
  56. Caldwell, R. A., Vyavahare, N., Langan III, E. M., & LaBerge, M. (2003). Matrix metalloproteinase inhibitor within an absorbable coating for vascular applications: delivery device characterization and the reduction of smooth muscle cell proliferation and migration. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 67(1), 1-10.
  57. Sacks, M. S., & Schoen, F. J. (2002). Collagen fiber disruption occurs independent of calcification in clinically explanted bioprosthetic heart valves. Journal of Biomedical Materials Research: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 62(3), 359-371.
  58. Bailey, M., Xiao, H., Ogle, M., & Vyavahare, N. (2001). Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. The American journal of pathology, 159(6), 1981-1986.
  59. Lovekamp, J., & Vyavahare, N. (2001). Periodate‐mediated glycosaminoglycan stabilization in bioprosthetic heart valves. Journal of Biomedical Materials Research: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 56(4), 478-486.
  60. Alferiev, I., Vyavahare, N., Song, C., Connolly, J., Hinson, J. T., Lu, Z., ... & Levy, R. (2001). Bisphosphonate derivatized polyurethanes resist calcification. Biomaterials, 22(19), 2683-2693.
  61. Alferiev, I. S., Vyavahare, N. R., Song, C. X., & Levy, R. J. (2001). Elastomeric polyurethanes modified with geminal bisphosphonate groups. Journal of Polymer Science Part A: Polymer Chemistry, 39(1), 105-116.