ORTHOPAEDIC BIOENGINEERING LABORATORY


Selected Journal Publications


  1. Durig N, Wu Y, Chiaramonti AM, Barfield WR, Yao H, Pellegrini VD, Jr. Functional Flexion Instability in Rotating Platform Total Knee Arthroplasty. The Journal of Bone & Joint Surgery, 2020, 102(19), 1694-1702.
  2. Wu Y, Cisewski SE, Matthew C, Wei F, She X, Kern MJ, Gonzalez YM, Gallo LM, Iwasaki LR, Nickel JC, Yao H. Effect of Sustained Joint Loading on TMJ Disc Nutrient Environment. Journal of Dental Research. 2019, 98(8), 888-895.
  3. Gross R, Wu Y, Bonthius D, Gross V, Smith AC, McCrackin MA,Wolfe M, Helke KL, Yao H, Creation of a Porcine Kyphotic Model, Spine Deformity, 2019, 7(2), 213-219.
  4. Wu Y, Hanna EL, Holmes RE, Lin Z, Chiaramonti AM, Reeves RA, Vanek KN, Barfield WR, Yao H, Pellegrini VD, Jr. External Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model. Clinical Orthopaedics and Related Research. 2018, 476(10), 2076-2090.
  5. Worley ML, Patterson TM, Graboyes EM, Wu Y, Brody RM, Hornig J, Walton Z. Association of the Anterolateral Thigh Osteomyocutaneous Flap With Femur Structural Integrity and Assessment of Prophylactic Fixation. JAMA Otolaryngology–Head & Neck Surgery. 2018, 144(9), 769-775.
  6. Wright GJ, Coombs MC, Wu Y, Damon BJ, Bacro TH, Kern MJ, Chen X, Yao H. Electrical Conductivity Method to Determine Sexual Dimorphisms in Human Temporomandibular Disc Fixed Charge Density. Annals of Biomedical Engineering. 2018, 46(2), 310-317.
  7. Cisewski SE#, Wu Y#, Damon BJ, Sachs BL, Kern MJ, Yao H. Comparison of Oxygen Consumption Rates of Nondegenerate and Degenerate Human IVD Cells. Spine. 2018, 43(2), E60-E67.(#: Equal contribution)
  8. Wu Y, Cisewski SE, Sun Y, Brooke DJ, Sachs BL, Pellegrini VD Jr, Slate EH, Yao H. Quantifying baseline fixed charge density in healthy human cartilage endplate: a two-point electrical conductivity method. Spine. 2017, 42(17), E1002-E1009.
  9. Wu Y, Cisewski SE, Wei F, She X, Gonzales TS, Iwasaki LR, Nickel JC, Yao H. Fluid pressurization and tractional forces during TMJ disc loading: A biphasic finite element analysis. Orthodontics & Craniofacial Research. 2017, 20(S1), 151-156.
  10. Wu Y, Cisewski SE, Wegner N, Zhao S, Pellegrini VD, Jr., Slate EH, Yao H. Region and strain-dependent diffusivities of glucose and lactate in healthy human cartilage endplate. Journal of Biomechanics. 2016, 49(13), 2756-62.
  11. Cisewski SE, Zhang L, Kuo J, Wright GJ, Wu Y, Kern MJ, and Yao H. The effects of oxygen level and glucose concentration on the metabolism of porcine TMJ disc cells. Osteoarthritis and Cartilage. 2015, 23(10), 1790-6.
  12. Wu Y, Cisewski SE, Sachs BL, Pellegrini VD, Jr., Kern MJ, Slate EH, Yao H. The region-dependent biomechanical and biochemical properties of bovine cartilaginous endplate. Journal of Biomechanics. 2015, 48(12), 3185-91.
  13. Wu Y, Kuo J, Wright GJ, Cisewski SE, Wei F, Kern MJ, Yao H. Viscoelastic Shear Properties of Porcine Temporomandibular Joint Disc. Orthodontics and Craniofacial Research. 2015, 18(S1), 156-163.
  14. Hepfer RG, Shi C, Wu Y, Waring GO, and Yao H. Corneal Cross-linking: Engineering a Predictable Model, Critical Reviews in Biomedical Engineering. 2014, 42, 229-248.
  15. Wu Y, Cisewski S, Sachs BL, Yao H. Effect of cartilage endplate on cell based disc regeneration: a finite element analysis. Molecular & Cellular Biomechanics. 2013, Jun; 10(2), 159-82.

Conference Proceedings


  1. Sun Y, Walker L, Groke M, Brock M, Sachs B, Reitman C, Yao H, Wu Y, Biomechanical Characterization of Human Cervical Cartilage Endplate in Degenerate Disc. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
  2. Ye T, Li Y, Nadeau E, Reeves R, Le M, Lutas M; Watkins B, Gannon S, Fan H; Pellegrini VD, Yao H, Wu Y, Cigarette Smoke Exposure Increases Severity of Cartilage Degradation in Rats with Femoral Fractures. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
  3. Wang S, Wu Y, Mah E, Chen Z, Greene E, Brockbank K, Yao H, Distribution of Loaded Cryoprotectants in Meniscal Tissues for Ice-free Cryopreservation. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
  4. Chen P, Chen Z, Ren P, Hepfer G, Greene E, Campbell L, Brockbank K, Wu Y, Yao H, Nanowarming and Ice-free Cryopreservation of Large Articular Cartilage. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
  5. Bonthius DJ, Gross RH, Wu Y, Alshareef M, and Yao H, Rib-hook Construct For Pediatric Hyperkyphosis And Kyphoscoliosis. 66th Annual Meeting of Orthopaedic Research Society (ORS), Phoenix, AZ, 2020. ORS Spine Podium Award
  6. She X, Wu Y, Kern MJ, Lee JS, and Yao H, “Sexual Dimorphisms of Joint Loading Influence TMJ Disc Nutrient Environment,” The 2020 IADR/AADR Annual Meeting, Washington, DC, 2020. Finalist of Dr. Bernard G. Sarnat (Senior) Awards
  7. Wu Y, Sun Y, Groke M, Beall L, Brock M, Sachs B, Reitman C. Morphological, Biochemical and Biomechanical Characterization of Human Cervical Endplate in Degenerated Disc. 47th Annual Meeting of Cervical Spine Research Society (CSRS), New York, NY. 2019.
  8. Wu Y, Ren P, Chen P, Reitman C, Pellegrini VD, Yao H. Effect of Smoke Exposure on Intervertebral Disc Degeneration: A Rat Model. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
  9. Ren P, Wu Y, Chen P, Coombs M, Sachs B, Reitman C, Niu H, Gong H, Yao H. Relationship between Diffusion Properties and Tissue Calcification in Human Cartilage Endplate. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
  10. Reeves RA, Wu Y, Hefter GD, Barfield WP, Pellegrini VD. Establishment of a Cigarette Smoke-Exposure Protocol for the Study of Fracture Healing in a Bilateral Femur Fracture Model. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
  11. Walsh RC, Wu Y, Reeves RA, Hefter GD, Nadeau E, Barfield WP, Pellegrini VD. Effects of Cigarette Smoke Exposure on the Mechanical Strength of Femur Fracture Healing. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
  12. Wu Y, Cisewski SE, Wei F, Kern MJ, Gallo LM, Gonzales TS, Iwasaki LR, Nickel JC, Yao H. Determining TMJ Disc Nutrient Environment Under Load: A Bioengineering Approach. 47th Annual Meeting of the American Association for Dental Research (AADR), Fort Lauderdale, FL. 2018.
  13. Bonthius D, Wu Y, Gallien T, DeMcCrackin MA, Yao H. Effect of the rib construct on growth modulation of a fixed kyphotic deformity in a porcine model. 64th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2018.
  14. Wu Y, Lin Z, Hanna EL, Holmes RE, McDonald DG, Vanek KN, Yao H, Barfield W, Pellegrini VD, Jr. A Quantitative µCT & Histomorphometry Analysis of Preferential Radiation Effect on the Endochondral Bone Ossification. The 63th Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
  15. Durig NE, Wu Y, Pellegrini VD, Jr. Polyethylene Insert Subluxation in Rotating Platform Total Knee Arthroplasty: The Role of Flexion/Extension Gap Laxity. The 63th Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
  16. Lin Z, Wu Y, Hanna EL, Holmes RE, Barfield WR, McDonald DG, Vanek KN, Yao H, Pellegrini VD, Jr. Effect of External Beam Irradiation on the Acquisition of Biomechanical Strength in Rat Femurs Healing via Two Bone Healing Pathways. The 63th Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
  17. Cisewski SE, Wu Y, Sachs BL, Kern MJ, Yao H. Comparison of Glucose Consumption and Lactate Production Rates and Mitochondrial Membrane Potential of Human Intervertebral Disc Cells. The 63th Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017. Finalist of ORS Spine Poster Award
  18. Durig NE, Wu Y, Pellegrini VD, Jr. Polyethylene Insert Subluxation in Rotating Platform Total Knee Arthroplasty: The Role of Flexion/Extension Gap Laxity. The 34th Annual Meeting of the Southern Orthopaedic Association (SOA), Hilton Head, SC. 2017.
  19. Lin Z, Wu Y, Hanna EL, Holmes RE, Barfield WR, McDonald DG, Vanek KN, Yao H, Pellegrini VD, Jr. Effect of External Beam Irradiation on the Acquisition of Biomechanical Strength in Rat Femurs Healing via Two Bone Healing Pathways. The 33th Annual Meeting of the Southern Orthopaedic Association (SOA), Naples, FL. 2016. Presidents’ Resident Award: Highlight at 2017 American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting
  20. Holmes RE, Hanna EL, Wu Y, Barfield WR, Stains J, Vanek K, McDonald D, Pellegrini VD, Jr. Differential Effects of External Beam Irradiation on the Pathway of Fracture Healing by Inhibition of Genetic Expression. The 47th Eastern Orthopaedic Association (EOA) Annual Meeting, New Orleans, LA. 2016. Founders’ Award: Highlight at 2017 American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting
  21. Wu Y, Cisewski SE, Slate EH, Pellegrini VD Jr, Yao H. Role of Cartilage Endplate in Disc Mechanics and Nutrition. 62th Annual Meeting of Orthopedic Research Society (ORS), Orlando, FL. 2016. Finalist of New Investigator Recognition Award (NIRA)
  22. Wu Y, Cisewski SE, Sachs BL, Yao H. Oxygen Consumption Rates of Degenerated and Non-degenerated Human IVD Cells. The 3rd International Philadelphia Spine Research Symposium (IPSRS), Philadelphia, PA. 2015.
  23. Wu Y, Hanna EL, McDonald DG, Vanek KN, Yao H, Pellegrini VD Jr. Effect of External Beam Irradiation on the Pathway of Bone Fracture Healing. The 2015 Annual Meeting of the Orthopaedic Trauma Association (OTA), San Diego, CA. 2015.
  24. Wu Y, Hanna EL, McDonald DG, Vanek KN, Yao H, Pellegrini VD Jr. Effect of External Beam Irradiation on the Pathway of Bone Fracture Healing. The 32th Annual Meeting of the Southern Orthopaedic Association (SOA), Asheville, NC. 2015. Poster Award
  25. Hanna EL, Wu Y, Holmes RE, Barfield WR, Yao H, Pellegrini VD Jr. Influence of Method of Repair on the Pathway and Efficacy of Fracture Healing. The 32th Annual Meeting of the Southern Orthopaedic Association (SOA), Asheville, NC. 2015.
  26. Wu Y, Wright G, Wei F, Yao H. Tractional Force on Temporomandibular Joint Disc: A Finite Element Analysis. The 44th Annual Meeting of the International/American/Canadian Association for Dental Research (IADR/AADR/CADR), Boston, MA. 2015. Podium Session Chair
  27. Wright G, Wu Y, Berry J, Cisewski S, Bacro T, Yao H. Tensile Stress Relaxation Properties of Human TMJ Disc. The 44th Annual Meeting of the International/American/Canadian Association for Dental Research (IADR/AADR/CADR), Boston, MA. 2015.
  28. Wu Y, Wei F, Berry J, Damon B, Yao H. Multi-scale Computational Techniques: When you can’t do it with a physical experiment….model the problem. Consortium for Orthodontic Advances in Science & Technology (FASEB SRC), Itasca, IL. 2014.
  29. Wu Y, Cisewski SE, Sachs BL, Yao H. Biomechanical and Biochemical Characterization of Human Cartilage Endplate and Its Role in Disc Mechanics and Nutrition. 7th World Congress of Biomechanics (WCB), Boston, MA. 2014.
  30. Damon B, Wu Y, Cisewski SE, Sachs BL, Yao H. Effect of Nutrient Deprivation on Intervertebral Disc Cell Volume Regulation. 60th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2014.
  31. Wright GJ, Wu Y, Gross RH, Cisewski SE, Sachs BL, Yao H. A Biomechanical Investigation of Thoracic Hyperkyphoscoliosis in EOS Treated with Rib Fixation. 60th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2014.
  32. Wu Y, Cisewski SE, Ahmad AA, Gross RH, Yao H. Effect of Cartilage Endplate on Cell Based Disc Regeneration: A Finite Element Analysis. 58th Annual Meeting of Orthopedic Research Society (ORS), San Francisco, CA. 2012.
  33. Cisewski SE, Wu Y, Baatz JE, Sachs BL, Glaser JA, Yao H. Nutrition Metabolic Rates of Normal Human Intervertebral Disc Cells. 58th Annual Meeting of Orthopedic Research Society (ORS), San Francisco, CA. 2012.
  34. Wu Y, Cisewski SE, Sachs B L, Glaser J A, Yao H. Oxygen Consumption Rate of Human Intervertebral Disc Cells. The 57th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, 2011.
  35. Wu Y, Kuo J, Cisewski SE, Zhang L, Yao H. Viscoelastic Properties of Bovine Cartilaginous Endplate. The 56th Annual Meeting of Orthopaedic Research Society (ORS), New Orleans, LA, 2010.
  36. Wu Y, Kuo J, Zhang L, and Yao H. Effect of Endplate and Mechanical Loading on Solute Transport in Human IVD. 2008 ASME Summer Bioengineering Conference, Marco Island, FL, 2008.
  37. Wu Y, Glaser J, and Yao H. Viscoelastic Shear Properties of Porcine TMJ Discs. The 37th Annual Meeting of the American Association for Dental Research (AADR), Dallas, TX, 2008.
  38. Kuo J, Wu Y, Yun J, and Yao H. Viscoelastic Compressive Properties of Porcine TMJ Disc and Condyle Cartilage. The 37th Annual Meeting of the American Association for Dental Research (AADR), Dallas, TX, 2008.