ORTHOPAEDIC BIOENGINEERING LABORATORY

2025 Journal Publications

• Fort MW, Nelton E, Chiaramonti A, Wu Y, Pellegrini VD, Jr., Revisiting the Critical Pathology of Thumb Basal Joint Osteoarthritis: Is it Volar or Dorsal? The Journal of Bone & Joint Surgery, 2025 (in press).
• Gordon D, Sun S, Walker L, Buchweitz N, Zhao J, Mah E, Sumwalt C, Baek J, Blake-Wade K, Bain N, Slate E, Chiaramonti A, Daley D, Yao H, Wu Y, Association of Ligament Mechanical Properties and Articular Surface Topography with Trapeziometacarpal Kinematics Across Osteoarthritis Stages, Osteoarthritis and Cartilage, 2025 (in press).
• Buchweitz N, Sun Y, Kelley J, Cisewski- Porto S, Wang S, Reitman C, Yao H, Wu Y,Characterizing the Baseline Regional Biphasic Mechanical Properties of Cervical Intervertebral Discs, Annals of Biomedical Engineering, 2025 Sep; 53(9):2333-2345.
• Bonthius D, Gross R, Alshareef M, Wright G, Sun S, Wu Y, Yao H, Rib construct for severe spinal deformity in young children: a 3-part investigation of biomechanical, animal, and clinical case data, North American Spine Society Journal, 2025 Jul 30; 100776.
• Walker L, Li H, Buchweitz N, Gordon D, Wang S, Daley D, Yao H, Wu Y, Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints, Annals of Biomedical Engineering, 2025 Jun; 53(6), 1471-1485.
• Li H*, Kelley J*, Ye Y, Ye ZW, Townsend DM, Zhang J, Wu Y, REDOX Imbalance and Oxidative Stress in the Intervertebral Disc: The Effect of Mechanical Stress and Cigarette Smoking on ER Stress and Mitochondrial Dysfunction, Cells, 2025 Apr 19; 14(8):613. (*: Equal contribution).
• Walker L, Gordon D, Chiaramonti A, Wang S, Meng Z, Daley D, Slate E, Yao H, Pellegrini VD, Wu Y, Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints, Annals of Biomedical Engineering, 2025 Apr; 53:799-811.
  • Received the Athanasiou Student and Postdoc Manuscript Award.
• Buchweitz N, Sun Y, Cisewski- Porto S, Wang S, Reitman C, Yao H, Wu Y, Characterizing the Baseline Fixed Charge Density in Human Cervical Intervertebral Discs, Journal of Biomechanics, 2025 Mar; 181:112554.
• Kelley J*, Li H*, Sun Y, Ren P, Chen G, Sun S, Zhao J, Buchweitz N, Kern M, Reitman C, Townsend D, Yao H, Wu Y, Endplate Remodeling: A Key Indicator of Cigarette Smoke Exposure-Induced Intervertebral Disc Degeneration in a Male Rat Model, Journal of Bone and Mineral Research Plus, 2025 Jan 27; 9(5):ziaf016. (*: Equal contribution).
• Thomas V, Buchweitz N, Wu Y, Mercuri J, Evaluation of Cartilage-Like Matrix Formation in a Nucleus Pulposus-Derived Cartilage Analog Scaffold, Journal of Biomedical Materials Research Part B - Applied Biomaterials, 2025 Jan 10; 113(1):e35534.
• Reeves RA*, Wu Y*, Hanna E, Holmes R, Chiaramonti A, Nadeau E, Lin Z, Westbrook P, Hefter G, Ryan W, Barfield WR, Pellegrini VD, Jr. Cigarette Smoke Exposure Impairs Fracture Healing in a Rat Model: Preferential Impairment of Endochondral over Membranous Healing, Journal of Biomechanical Engineering, 2025 Jan; 147(1)011005. (*: Equal contribution)

2025 Conference Proceedings

• Gordon D, Tang Z, Walker L, Chiaramonti A, Daley D, Yao H, Hoover A, Wu Y, Using Machine Learning To Classify Trapeziometacarpal Osteoarthritis Based On Bony Morphology, Kinematic Performance, And Soft-tissue Mechanical Properties, 80th Annual Meeting of The American Society for Surgery of the Hand (ASSH), Vancouver, BC, Canada, October 9-11, 2025.
• Walker L, Gordon D, Li H, Mukherji M, Zhang R, Daley D, Meng Z, Ye T, Yao H, Pellegrini Jr. VD, Wu Y, Microarchitecture And Micromechanical Deterioration Of The Volar Ligament Complex At The Metacarpal Enthesis In Female Osteoarthritic Trapeziometacarpal Joints. Presented at the 80th Annual Meeting of The American Society for Surgery of the Hand (ASSH), Vancouver, BC, Canada. October 9-11, 2025.
• Hui L, Yang Z, Kelley J, Tong Y, Reitman C, Yao H, Wu Y, Effects of Microarchitecture Remodeling on Disc-Bone Interface Micromechanics in a Smoke-Exposure Rat Model, 71st Annual Meeting of Orthopaedic Research Society (ORS), Pheonix, AZ, February 7-11, 2025.
• Sun S, Xu P, Buchweitz N, She X, Wilson M, Ahmadi F, Mei A, Hill C, Lee JS, Wu Y, Yao H, Identifying Temporomandibular Disorder Morphological Risk Factors via Deep Learning and Multiscale Biomechanical Modeling, 71st Annual Meeting of Orthopaedic Research Society (ORS), Pheonix, AZ, February 7-11, 2025.
• Walker L, Gordon D, Kelley J, Mukherji M, Zhang R, Daley D, Meng Z, Pellegrini VD, Jr., Ye T, Yao H, Wu Y, Beak Ligament Microarchitecture Deteriorates at Metacarpal Enthesis in Female Osteoarthritic Trapeziometacarpal Joints, 71st Annual Meeting of Orthopaedic Research Society (ORS), Pheonix, AZ, February 7-11, 2025.
• Yang Z, Wang H, Wu Y, Meng Z, Understanding the Effects of Composition and Structure on the Mechanical Properties of Tendon-Bone Insertion Using Mesoscale Computational Modeling, 71st Annual Meeting of Orthopaedic Research Society (ORS), Pheonix, AZ, February 7-11, 2025.

2024 Journal Publications

• Kelley J, Buchweitz N, Madden A, Fan H, Hepfer G, Kern M, Townsend D, Ye T, Yao H, Wu Y, Effect of Cigarette Smoke Exposure and Cessation on Regional Diffusion Properties in Rat Intervertebral Discs, Journal of Orthopaedic Research-Spine, 2024 Nov 14; 7(4):e70015.
• Yang Z, Gordon D, Chen Y, Li H, Wu Y, Meng Z. Understanding the Effects of Composition and Structure on the Mechanical Properties of Tendon-Bone Insertion Using Mesoscale Computational Modeling, Journal of the Mechanical Behavior of Biomedical Materials, 2024 Sep 10:160:106735.
• Sun S*, Xu P*, Buchweitz N*, She X, Wilson M, Ahmadi F, Mei A, Hill C, Lee JS, Wu Y#, Yao H#, Explainable deep learning and biomechanical modeling for TMJ disorder morphological risk factors, Journal of Clinical Investigation Insight, 2024 Jul 11; 9(16):e178578. (*Equal contribution; #Co-corresponding author).
• Buchweitz N, Sun Y, Porto S, Kelley J, Reitman C, Slate E, Wang S, Meng Z, Yao H, Wu Y, Regional structure-function relationships of lumbar cartilage endplates, Journal of Biomechanics, 2024 May:169:112131.
• DiNicola ES, Martinez AV, Walker L, Wu Y, Burnikel BG, Mercuri J. Cigarette Smoke Extract Promotes the Destruction of Cartilage Explants in an in vitro OA Model, Journal of Orthopaedic Research, 2024 Mar; 42(8):1682-1695.
• Thomas V, Buchweitz N, Baek J, Wu Y, Mercuri J. The Development of a Nucleus Pulposus-Derived Cartilage Analog Scaffold for Chondral Repair and Regeneration, Journal of Biomedical Materials Research: Part A, 2024 Mar; 112(3):421-435.
• Wang S, Mueller D, Chen P, Emerson L, Mah E, Pan G, Chen Z, Greene ED, Wu Y, Brockbank KGM, Yao H. Viable Vitreous Grafts of Whole Porcine Menisci for Transplant in the Knee and Temporomandibular Joints, Advanced Healthcare Materials, 2024 Mar; 24:e2303706.
• Caviness C, Chen Y, Yang Z, Wang H, Wu Y, Meng Z, Improved Ballistic Impact Resistance of Nanofibrillar Cellulose Films with Discontinuous Fibrous Bouligand Architecture, Journal of Applied Mechanics, 2024 Feb, 91(2): 021003.

2024 Conference Proceedings

• Yang Z, Wang H, Wu Y, Meng Z, Effect of Composition and Structure on Mechanical Properties of Tendon-to-bone Insertion, 2024 Society of Engineering Science Annual Technical Meeting, Hangzhou, China, August 20-23, 2024.
• Slone HS, Lynch MK, Pullen WM, Goodloe J, Wu Y, Helke K, Yao H, Wang S, Brockbank KG, Ashy C. Nanowarming by Inductive Heating of Vitrified Large Articular Cartilage Specimens, 2024 Annual Meeting of the Arthroscopy Association of North America (AANA), Boston, MA, May 9-11, 2024.
• Sun S, Ahmadi F, Sagl B, Hill C, Wu Y, and Yao H, Modeling TMJ Pain with Structural and Neurological Interaction, 2024 American Association for Dental, Oral, and Craniofacial Research (AADOCR)/ Canadian Association for Dental Research (CADR) Annual Meeting, New Orleans, LA, March 13-16, 2024.
• Gross R, Bonthius D, Alsshareef M, Saway B, Wu Y, Yao H, Thoracic Realignment with Proximal Rib Fixation is a Safe and Effective Method for Managing Severe Pediatric Spinal Deformity, 2024 Annual Meeting of American Academy of Orthopaedic Surgeons (AAOS), San Francisco, CA, February 12-16, 2024.
• Buchweitz N, Porto S, Kelley J, Slate E, Yao H, Wu Y, Regional Structure-Function Relationships of Lumbar Cartilage Endplate, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.
• Gordon D, Li H, Newton W, Yang Z, LaRochelle L, Fan H, Ye T, Yao H, Meng Z, Wu Y, Impact of Cigarette Smoke Exposure on Structural and Mechanical Properties of Rat Supraspinatus Tendon, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.
• Gordon D, Walker L, Sun S, Baek J, Chiaramonti A, Mah E, Wolfe J, Daley D, Yao H, Wu Y, Impact of Ligament Integrity on Trapeziometacarpal Joint Stability, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.
• Kelley J, Allen T, Sun S, Mignone I, Buchweitz N, Fan H, Ye T, Yao H, Wu Y, Effect of Cigarette Smoke Exposure on Intervertebral Disc Remodeling Using a Sprague Dawley Rat Model, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.
• Walker L, Gordon D, Wang S, Mah E, Daley D, Yao H, Wu Y, A Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.
• Wang S, Chen P, Mueller D, Pan G, Wilson M, Sun S, Chen Z, Lee T, Damon B, Hepfer G, Hill C, Wu Y, Brockbank K, Yao H, Advancing Fresh, Viable Meniscal Allograft Preservation: Ice-free Vitrification in a Pig Model, 70th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, February 2-4, 2024.

2023 Journal Publications

• Ren P, Chen P, Buchweitz N, Reeves R, Reitman CA, Niu H, Gong H, Yao H, Wu Y, Diffusivity of Human Cartilage Endplates in Healthy and Degenerated Intervertebral Disks, Journal of Biomechanical Engineering, 2023 Jul 1; 145(7):071006.
• Chen P, Wang S, Che Z, Ren P, Hepfer G, Greene E, Campbell L, Helke K, Nie X, Jensen J, Hill C, Wu Y, Brockbank K, Yao H, Nanowarming and ice-free cryopreservation of large sized, intact articular cartilage, Nature Communication Biology, 2023 Feb 24; 6(1):220.
• Carson MD, Warner AJ, Hathaway-Schrader JD, Geiser VL, Kim J, Gerasco JE, Hill WD, Lemasters JJ, Alekseyenko AV, Wu Y, Yao H, Aguirre JI, Westwater C, Novince CM, Minocycline-Induced Disruption of the Intestinal FXR-FGF15 Axis Impairs Osteogenesis in Mice. Journal of Clinical Investigation Insight, 2023 Jan 10; 8(1):e160578.

2023 Conference Proceedings

• Walker L, Gordon D, Chiaramonti A, Daley D, Yao H, Wu Y, Comparison of Viscoelastic Ligament Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints, IDeA South Eastern Region Conference, Columbia, September 15-17, 2023.
• Second Place Poster Award (Biomedical Engineering Category)
• Fort MW, Nelton E, Chiaramonti A, Wu Y, Pellegrini VD, Jr., Revisiting the Critical Pathology of Thumb Basal Joint Osteoarthritis: Is it Volar or Dorsal? 78th Annual Meeting of the American Society for Surgery of the Hand (ASSH), Toronto, Ontario, Canada, October 5-7, 2023.
  • "Best Paper" (Podium Category)
  • 2023 NYSSH Emanuel B. Kaplan Award
• Brockbank KGM, Wang S, Lynch MK, Goodloe J, Chen P, Ren P, Hepfer G, Greene E, Campbell LH, Slone H, Pullen W, Wu Y, Yao H, Helke K. Outcomes of the First in Vivo Study of Osteochondral Allografts after Cryopreservation by Vitrification with Nanowarming in a Porcine Model, American Association of Tissue Banks (AATB) Annual Meeting, National Harbor, MD, 2023.
• Sun S, Ahmadi F, Hill C, Almpani K, Jani P, Damon B, Sagl B, Wu Y, Yao H, Lee J, Bite Force Control Capacity Differs Between Dentofacial Differences and Improves with Orthognathic Surgery, 105th American Association of Oral and Maxillofacial Surgeons (AAOMS) Annual Meeting, San Diego, CA, September 18-23, 2023.
• Sun S, Xu P, Buchweitz N, She X, Wilson M, Ahmadi F, Mei A, Hill C, Lee JS, Wu Y, Yao H, Identifying Temporomandibular Disorder Morphological Risk Factors via Deep Learning and Multiscale Biomechanical Modeling, International TMJ Interdisciplinary Research Meeting, Philadelphia, PA April 21-22, 2023.
• Sun S, Ahmadi F, Hill C, Almpani K, Jani P, Damon B, Sagl B, Wu Y, Lee J, Yao H, Evaluating Bite Force Control Capacity Before and After Orthognathic Surgery, 2023 American Association for Dental, Oral, and Craniofacial Research (AADOCR)/ Canadian Association for Dental Research (CADR) Annual Meeting, Portland, OR, March 15-18, 2023.
• Kelley J, Buchweitz N, Fan H, Wang S, Hepfer GR, Reitman C, Ye T, Yao H, Wu Y, Effect of Cigarette Smoke Exposure on Intervertebral Disc Biomechanical Properties: A Rat Model, 69th Annual Meeting of Orthopaedic Research Society (ORS), Dallas, TX, February 10-14, 2023.
• Walker L, Gordon D, Chiaramonti A, Daley D, Yao H, Wu Y, Comparison of Viscoelastic Ligament Properties in Healthy and Osteoarthritic TMC Joints, 69th Annual Meeting of Orthopaedic Research Society (ORS), Dallas, TX, February 10-14, 2023.
• Wang S, Chen P, Mueller D, Hepfer GR, Jones AL, Campbell L, Wu Y, Brockbank KGM, Yao H, Impact of Post-Mortem Time and Temperature on Biomaterial Properties of Human Peroneus Longus Tendons, 69th Annual Meeting of Orthopaedic Research Society (ORS), Dallas, TX, February 10-14, 2023.

2022 Journal Publications

• Kang IH, Baliga U, Chatterjee S, Chakraborty P, Choi S, Buchweitz N, Li H, Wu Y, Yao H, Mehrotra S, Mehrotra M. Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta. iScience, 2022 Aug 5; 25(9):104818.

2022 Conference Proceedings

• Sun S, Xu P, Buchweitz N, She X, Wilson M, Ahmadi F, Mei A, Hill C, Lee JS, Wu Y, Yao H, Identifying Temporomandibular Disorder Morphological Risk Factors via Deep Learning and Multiscale Biomechanical Modeling, The Perry V. Halushka MUSC Research Day, Charleston, SC, November 7, 2022.
• First Place Oral Presentation
• Interprofessional Collaboration Research Award
• Fort MW, Chiaramonti A, Wu Y, Pellegrini VD, Jr. Revisiting the Critical Pathology of Thumb Basal Joint Osteoarthritis: Is it Volar or Dorsal? 77th Annual Meeting of the American Society for Surgery of the Hand (ASSH), Boston, Massachusetts, September 29-October 1, 2022.
• Chen P, Wang, S, Chen Z, Goodloe J, Ren P, Hepfer G, Greene E, Campbell LH, Wu Y, Helke K, Slone H, Brockbank KGM, Yao H. Nanowarming of Large Porcine Osteochondral Tissues: In vitro and Simulation Studies. Oral Presentation, the 59th Annual Meeting of Society for Cryobiology, Dublin, Ireland, July 19-22, 2022.
• Burnikel A, Goodloe JB, Brockbank KGM, Yao H, Angel P, Helke K, Wu Y, Slone HS. Nanowarming by Inductive Heating of Vitrified Large Articular Cartilage Specimens, In Vivo Testing with Hanford Mini Pigs. American Orthopaedic Society for Sports Medicine (AOSSM) Annual Meeting. Colorado Springs, CO, July 13-17, 2022.
• Thomas V, Buchweitz N, Wu Y, Mercuri J. The Mechanical Characterization of a Novel Cartilage Repair Scaffold, Society for Biomaterials 2022 Annual Meeting, Baltimore, Maryland, April 27-30, 2022.
• Brockbank KG, Chen P, Wang S, Chen Z, Ren P, Hepfer RG, Greene ED, Campbell LH, Helke KL, Wu Y, Yao H. Progress in Cartilage Cryopreservation using Nanowarming and Ice-free Vitrification. Poster presentation, 16th World Congress of the International Cartilage Regeneration & Joint Preservation Society, Berlin, Germany, April 12–15, 2022.
• Walker L, Sun S, Gordon D, Bain N, Chiaramonti A, Nadeau E, Daley D, Yao H, Wu Y, Kinematic Analysis of Functional Motions in Healthy and Osteoarthritic Human TMC Joints: An Optical Motion Tracking Approach, 68th Annual Meeting of Orthopaedic Research Society (ORS), Tampa, FL, February 4-8, 2022.
• Chen P, Wang S, Chen Z, Goodloe J, Ren P, Hepfer G, Greene E, Campbell L, Wu Y, Helke K, Slone H, Brockbank K, Yao H, Nanowarming and Ice-free Cryopreservation Of Large Articular Cartilage: In Vitro And In Vivo Studies, 68th Annual Meeting of Orthopaedic Research Society (ORS), Tampa, FL, February 4-8, 2022.
• Goodloe J, Brockbank K, Slone H, Wu Y, Yao H. Nanowarming and Ice-Free Cryopreservation of large Articular Cartilage Specimens, 2022 Annual Meeting of American Academy of Orthopaedic Surgeons (AAOS), Chicago, IL, March 22-26, 2022.

2021 Journal Publications

• Kang IH, Baliga UK, Wu Y, Mehrotra S, Yao H, LaRue AC, Mehrotra M. Hematopoietic stem cell-derived functional osteoblasts exhibit therapeutic efficacy in a murine model of Osteogenesis imperfecta. Stem Cells. 2021 Nov; 39(11):1457-77.

2021 Conference Proceedings

• Buchweitz N, Walker L, Sun Y, Groke M, Reitman C, Yao H, Wu Y. Biomechanical Characterization of Human Cervical Cartilage Endplate in Degenerate Disc. 49th Annual Meeting of Cervical Spine Research Society (CSRS), Atlanta, GA, 2021.
• She X, Wu Y, Chen P, Kern MJ, Lee JS, and Yao H. Sexual Dimorphisms of TMJ mechanics and Disc Nutrient Environment, 2021 International Association for Dental Research (IADR)/ American Association for Dental Research (AADR)/ Canadian Association for Dental Research (CADR) Annual Meeting, All Access, 2021.
• Goodloe J, Brockbank K, Slone H, Wu Y, Yao H. Nanowarming by Inductive Heating of Vitrified Large Articular Cartilage Specimens, 2021 Annual Meeting of Southern Orthopaedic Society (SOA), Isle of Palms, SC, 2021.
• Goodloe J, Brockbank K, Slone H, Wu Y, Yao H. Nanowarming by Inductive Heating of Vitrified Large Articular Cartilage Specimens, 2021 Annual Meeting of Eastern Orthopaedic Society (EOA), Nashville, TN, 2021.
• Sun Y, Walker L, Groke M, Brock M, Sachs B, Reitman C, Yao H, Wu Y. Biomechanical Characterization of Human Cervical Cartilage Endplate in Degenerate Disc. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
• Bonthius DJ, Gross RH, Wu Y, and Yao H. Rib Construct for Early-onset Spinal Deformity (EOSD). 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
• Ye T, Li Y, Nadeau E, Reeves R, Le M, Lutas M; Watkins B, Gannon S, Fan H; Pellegrini VD, Yao H, Wu Y. Cigarette Smoke Exposure Increases Severity of Cartilage Degradation in Rats with Femoral Fractures. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
• Wang S, Wu Y, Mah E, Chen Z, Greene E, Brockbank K, Yao H. Distribution of Loaded Cryoprotectants in Meniscal Tissues for Ice-free Cryopreservation. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.
• Chen P, Chen Z, Ren P, Hepfer G, Greene E, Campbell L, Brockbank K, Wu Y, Yao H. Nanowarming and Ice-free Cryopreservation of Large Articular Cartilage. 67th Annual Meeting of Orthopaedic Research Society (ORS), All Access, 2021.

20219 - 2020 Journal Publications

• Durig N, Wu Y, Chiaramonti AM, Barfield WR, Yao H, Pellegrini VD, Jr. Functional Flexion Instability in Rotating Platform Total Knee Arthroplasty. The Journal of Bone & Joint Surgery. 2020, Oct 7; 102(19):1694-1702.

2019 - 2020 Conference Proceedings

• Bonthius DJ, Gross RH, Wu Y, Alshareef M, and Yao H. Rib-hook Construct for Pediatric Hyperkyphosis and Kyphoscoliosis. 66th Annual Meeting of Orthopaedic Research Society (ORS), Phoenix, AZ, 2020.
• ORS Spine Podium Award
• She X, Wu Y, Kern MJ, Lee JS, and Yao H. Sexual Dimorphisms of Joint Loading Influence TMJ Disc Nutrient Environment, The 2020 IADR/AADR Annual Meeting, Washington, DC, 2020.
• Finalist of Dr. Bernard G. Sarnat (Senior) Awards
• Sun Y, Groke M, Beall L, Brock M, Sachs B, Reitman C, Yao H, Wu Y. Morphological, Biochemical and Biomechanical Characterization of Human Cervical Endplate in Degenerated Disc. 47th Annual Meeting of Cervical Spine Research Society (CSRS), New York, NY. 2019 (November 21-23)

Works Prior to 2019: Journal Publications

• Wu Y, Cisewski SE, Matthew C, Wei F, She X, Kern MJ, Gonzalez YM, Gallo LM, Iwasaki LR, Nickel JC, Yao H. Effect of Sustained Joint Loading on TMJ Disc Nutrient Environment. Journal of Dental Research. 2019 Jul, 98(8), 888-895.
• Gross R, Wu Y, Bonthius D, Gross V, Smith AC, McCrackin MA, Wolfe M, Helke KL, Yao H. Creation of a Porcine Kyphotic Model, Spine Deformity. 2019 Mar, 7(2), 213-219.
• Wu Y, Hanna EL, Holmes RE, Lin Z, Chiaramonti AM, Reeves RA, Vanek KN, Barfield WR, Yao H, Pellegrini VD, Jr. External Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model. Clinical Orthopaedics and Related Research. 2018 Oct, 476(10), 2076-2090.
• Worley ML, Patterson TM, Graboyes EM, Wu Y, Brody RM, Hornig J, Walton Z. Association of the Anterolateral Thigh Osteomyocutaneous Flap with Femur Structural Integrity and Assessment of Prophylactic Fixation. JAMA Otolaryngology–Head & Neck Surgery. 2018 Sep, 144(9), 769-775.
• Wright GJ, Coombs MC, Wu Y, Damon BJ, Bacro TH, Kern MJ, Chen X, Yao H. Electrical Conductivity Method to Determine Sexual Dimorphisms in Human Temporomandibular Disc Fixed Charge Density. Annals of Biomedical Engineering. 2018 Feb, 46(2), 310-317.
• Cisewski SE#, Wu Y#, Damon BJ, Sachs BL, Kern MJ, Yao H. Comparison of Oxygen Consumption Rates of Nondegenerate and Degenerate Human IVD Cells. Spine. 2018 Jan, 43(2), E60-E67. (#: Equal contribution)
• Wu Y, Cisewski SE, Sun Y, Brooke DJ, Sachs BL, Pellegrini VD Jr, Slate EH, Yao H. Quantifying baseline fixed charge density in healthy human cartilage endplate: a two-point electrical conductivity method. Spine. 2017 Sep, 42(17), E1002-E1009.
• Wu Y, Cisewski SE, Wei F, She X, Gonzales TS, Iwasaki LR, Nickel JC, Yao H. Fluid pressurization and tractional forces during TMJ disc loading: A biphasic finite element analysis. Orthodontics & Craniofacial Research. 2017 Jun, 20(S1), 151-156.
• Wu Y, Cisewski SE, Wegner N, Zhao S, Pellegrini VD, Jr., Slate EH, Yao H. Region and strain-dependent diffusivities of glucose and lactate in healthy human cartilage endplate. Journal of Biomechanics. 2016 Sep 6, 49(13), 2756-62.
• Cisewski SE, Zhang L, Kuo J, Wright GJ, Wu Y, Kern MJ, and Yao H. The effects of oxygen level and glucose concentration on the metabolism of porcine TMJ disc cells. Osteoarthritis and Cartilage. 2015 Oct, 23(10), 1790-6.
• Wu Y, Cisewski SE, Sachs BL, Pellegrini VD, Jr., Kern MJ, Slate EH, Yao H. The region-dependent biomechanical and biochemical properties of bovine cartilaginous endplate. Journal of Biomechanics. 2015 Sep, 48(12), 3185-91.
• Wu Y, Kuo J, Wright GJ, Cisewski SE, Wei F, Kern MJ, Yao H. Viscoelastic Shear Properties of Porcine Temporomandibular Joint Disc. Orthodontics and Craniofacial Research. 2015 Apr, 18(S1), 156-163.
• Hepfer RG, Shi C, Wu Y, Waring GO, and Yao H. Corneal Cross-linking: Engineering a Predictable Model, Critical Reviews in Biomedical Engineering. 2014, 42, 229-248.
• Wu Y, Cisewski S, Sachs BL, Yao H. Effect of cartilage endplate on cell-based disc regeneration: a finite element analysis. Molecular & Cellular Biomechanics. 2013 Jun; 10(2), 159-82.
• Steele SL, Wu Y, Yao H, Bell PD. Telomerase Immortalization of Principal Cells from Mouse Collecting Duct. American Journal of Physiology-Renal Physiology. 2010 Dec, 299(6), 1507-1514.

Works Prior to 2019: Conference Proceedings

• Wu Y, Ren P, Chen P, Reitman C, Pellegrini VD, Yao H. Effect of Smoke Exposure on Intervertebral Disc Degeneration: A Rat Model. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Ren P, Wu Y, Chen P, Coombs M, Sachs B, Reitman C, Yao H. Relationship between Diffusion Properties and Tissue Calcification in Human Cartilage Endplate. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Reeves RA, Wu Y, Hefter GD, Barfield WP, Pellegrini VD. Establishment of a Cigarette Smoke-Exposure Protocol for the Study of Fracture Healing in a Bilateral Femur Fracture Model. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Walsh RC, Wu Y, Reeves RA, Hefter GD, Nadeau E, Barfield WP, Pellegrini VD. Effects of Cigarette Smoke Exposure on the Mechanical Strength of Femur Fracture Healing. 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Reeves RA, Wu Y, Hefter GD, Nadeau E, Walsh RC, Barfield WP, Yao H, and Pellegrini VD, Cigarette Smoke Exposure Preferentially Impairs Endochondral Fracture Healing: Micro-CT Analysis, 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Nadeau E, Reeves RA, Hefter GD, Wu Y, Barfield WP, and Pellegrini VD, Preferential Effect of Cigarette Smoke on Cartilage Tissue Area During Fracture Healing, 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Gross RH, Bonthius DJ, Wu Y, Gross V, Smith A, Gallien T, and Yao H, Creation of a Porcine Model to Study Growth Modulation for Correction of Hyperkyphosis, 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Reeves RA, Nadeau E, Kelly R, Wu Y, Barfield WP, LaRue A, and Pellegrini VD, Circulating Osteoprogenitor Cell Number is Altered with Cigarette Smoke Exposure After Bilateral Femur Fracture, 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Nadeau E, Reeves RA, Yang L, Basunia R, Jonathan Y, Wu Y, Ye T, and Pellegrini VD, Cigarette Smoke Exposure Reduces Articular Chondrocyte Viability and Increases Cartilage Degradation, 65th Annual Meeting of Orthopedic Research Society (ORS), Austin, TX. 2019.
• Wu Y, Cisewski SE, Wei F, Kern MJ, Gallo LM, Gonzales TS, Iwasaki LR, Nickel JC, Yao H. Determining TMJ Disc Nutrient Environment Under Load: A Bioengineering Approach. 47th Annual Meeting of the American Association for Dental Research (AADR), Fort Lauderdale, FL. 2018.
• Bonthius D, Wu Y, Gallien T, DeMcCrackin MA, Yao H. Effect of the rib construct on growth modulation of a fixed kyphotic deformity in a porcine model. 64th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2018.
• Wu Y, Lin Z, Hanna EL, Holmes RE, McDonald DG, Vanek KN, Yao H, Barfield W, Pellegrini VD, Jr. A Quantitative µCT & Histomorphometry Analysis of Preferential Radiation Effect on the Endochondral Bone Ossification. The 63rd Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
• Durig NE, Wu Y, Pellegrini VD, Jr. Polyethylene Insert Subluxation in Rotating Platform Total Knee Arthroplasty: The Role of Flexion/Extension Gap Laxity. The 63rd Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
• Lin Z, Wu Y, Hanna EL, Holmes RE, Barfield WR, McDonald DG, Vanek KN, Yao H, Pellegrini VD, Jr. Effect of External Beam Irradiation on the Acquisition of Biomechanical Strength in Rat Femurs Healing via Two Bone Healing Pathways. The 63rd Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
• Cisewski SE, Wu Y, Sachs BL, Kern MJ, Yao H. Comparison of Glucose Consumption and Lactate Production Rates and Mitochondrial Membrane Potential of Human Intervertebral Disc Cells. The 63rd Annual Meeting of Orthopedic Research Society (ORS), San Diego, CA. 2017.
• Finalist of ORS Spine Poster Award
• Durig NE, Wu Y, Pellegrini VD, Jr. Polyethylene Insert Subluxation in Rotating Platform Total Knee Arthroplasty: The Role of Flexion/Extension Gap Laxity. The 34th Annual Meeting of the Southern Orthopaedic Association (SOA), Hilton Head, SC. 2017.
• Lin Z, Wu Y, Hanna EL, Holmes RE, Barfield WR, McDonald DG, Vanek KN, Yao H, Pellegrini VD, Jr. Effect of External Beam Irradiation on the Acquisition of Biomechanical Strength in Rat Femurs Healing via Two Bone Healing Pathways. The 33rd Annual Meeting of the Southern Orthopaedic Association (SOA), Naples, FL. 2016.
• Presidents’ Resident Award
• Highlight at 2017 American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting
• Holmes RE, Hanna EL, Wu Y, Barfield WR, Stains J, Vanek K, McDonald D, Pellegrini VD, Jr. Differential Effects of External Beam Irradiation on the Pathway of Fracture Healing by Inhibition of Genetic Expression. The 47th Eastern Orthopaedic Association (EOA) Annual Meeting, New Orleans, LA. 2016.
• Founders’ Award
• Highlight at 2017 American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting
• Wu Y, Cisewski SE, Slate EH, Pellegrini VD Jr, Yao H. Role of Cartilage Endplate in Disc Mechanics and Nutrition. 62nd Annual Meeting of Orthopedic Research Society (ORS), Orlando, FL. 2016.
• Finalist of New Investigator Recognition Award (NIRA)
• Highlight at 62nd Annual Meeting of Orthopedic Research Society (ORS)
• Wu Y, Cisewski SE, Sachs BL, Yao H. Oxygen Consumption Rates of Degenerated and Non-degenerated Human IVD Cells. The 3rd International Philadelphia Spine Research Symposium (IPSRS), Philadelphia, PA. 2015.
• Wu Y, Hanna EL, McDonald DG, Vanek KN, Yao H, Pellegrini VD Jr. Effect of External Beam Irradiation on the Pathway of Bone Fracture Healing. The 2015 Annual Meeting of the Orthopaedic Trauma Association (OTA), San Diego, CA. 2015.
• Wu Y, Hanna EL, McDonald DG, Vanek KN, Yao H, Pellegrini VD Jr. Effect of External Beam Irradiation on the Pathway of Bone Fracture Healing. The 32nd Annual Meeting of the Southern Orthopaedic Association (SOA), Asheville, NC. 2015.
• Poster Award
• Hanna EL, Wu Y, Holmes RE, Barfield WR, Yao H, Pellegrini VD Jr. Influence of Method of Repair on the Pathway and Efficacy of Fracture Healing. The 32nd Annual Meeting of the Southern Orthopaedic Association (SOA), Asheville, NC. 2015.
• Wu Y, Wright G, Wei F, Yao H. Tractional Force on Temporomandibular Joint Disc: A Finite Element Analysis. The 44th Annual Meeting of the International/American/Canadian Association for Dental Research (IADR/AADR/CADR), Boston, MA. 2015.
• Podium Session Chair
• Wright G, Wu Y, Berry J, Cisewski S, Bacro T, Yao H. Tensile Stress Relaxation Properties of Human TMJ Disc. The 44th Annual Meeting of the International/American/Canadian Association for Dental Research (IADR/AADR/CADR), Boston, MA. 2015.
• Wu Y, Wei F, Berry J, Damon B, Yao H. Multi-scale Computational Techniques: When you can’t do it with a physical experiment…. model the problem. Consortium for Orthodontic Advances in Science & Technology (FASEB SRC), Itasca, IL. 2014.
• Wu Y, Cisewski SE, Sachs BL, Yao H. Biomechanical and Biochemical Characterization of Human Cartilage Endplate and Its Role in Disc Mechanics and Nutrition. 7th World Congress of Biomechanics (WCB), Boston, MA. 2014.
• Damon B, Wu Y, Cisewski SE, Sachs BL, Yao H. Effect of Nutrient Deprivation on Intervertebral Disc Cell Volume Regulation. 60th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2014.
• Wright GJ, Wu Y, Gross RH, Cisewski SE, Sachs BL, Yao H. A Biomechanical Investigation of Thoracic Hyperkyphoscoliosis in EOS Treated with Rib Fixation. 60th Annual Meeting of Orthopedic Research Society (ORS), New Orleans, LA. 2014.
• Wu Y, Cisewski SE, Ahmad AA, Gross RH, Yao H. Effect of Cartilage Endplate on Cell Based Disc Regeneration: A Finite Element Analysis. 58th Annual Meeting of Orthopedic Research Society (ORS), San Francisco, CA. 2012.
• Cisewski SE, Wu Y, Baatz JE, Sachs BL, Glaser JA, Yao H. Nutrition Metabolic Rates of Normal Human Intervertebral Disc Cells. 58th Annual Meeting of Orthopedic Research Society (ORS), San Francisco, CA. 2012.
• Wu Y, Cisewski SE, Sachs B L, Glaser J A, Yao H. Oxygen Consumption Rate of Human Intervertebral Disc Cells. The 57th Annual Meeting of Orthopaedic Research Society (ORS), Long Beach, CA, 2011.
• Wu Y, Kuo J, Cisewski SE, Zhang L, Yao H. Viscoelastic Properties of Bovine Cartilaginous Endplate. The 56th Annual Meeting of Orthopaedic Research Society (ORS), New Orleans, LA, 2010.
• Wu Y, Kuo J, Zhang L, and Yao H. Effect of Endplate and Mechanical Loading on Solute Transport in Human IVD. 2008 ASME Summer Bioengineering Conference, Marco Island, FL, 2008.
• Wu Y, Glaser J, and Yao H. Viscoelastic Shear Properties of Porcine TMJ Discs. The 37th Annual Meeting of the American Association for Dental Research (AADR), Dallas, TX, 2008.
• Kuo J, Wu Y, Yun J, and Yao H. Viscoelastic Compressive Properties of Porcine TMJ Disc and Condyle Cartilage. The 37th Annual Meeting of the American Association for Dental Research (AADR), Dallas, TX, 2008.