DRUG DESIGN, DEVELOPMENT, AND DELIVERY
4D LABORATORY


Journal Publications

  1. Morgan Chandler, Lewis Rolband, M. Brittany Johnson, Da Shi, Yelixza I. Avila, Edward Cedrone, Damian Beasock, Leyla Danai, Elizabeth Stassenko, Joanna K. Krueger, Jiancheng Jiang, Jeoung Soo Lee, Marina A. Dobrovolskaia, Kirill A. Afonin. Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties, Accepted on Aug 1, 2022 in Advanced Functional Materials
  2. Christian Macks, Daun Jeong, and Jeoung Soo Lee. Rolipram by PgP nanocarrier reduces secondary injury and improves motor function in a rat mild TBI model. Nanomedicine (Lond). 2022 Mar;17(7):431-445. doi: 10.2217/nnm-2021-0271. Epub 2022 Feb 21. PMID: 35184609; PMCID: PMC8905552.
  3. Jun Gao, Min Kyeung Khang, Zhen Liao, Megan Detloff, and Jeoung Soo Lee. Therapeutic targets and nanomaterial-based therapy for mitigation of secondary injury after spinal cord injury. Nanomedicine (Lond). 2021 Sep;16(22):2013-2028. doi: 10.2217/nnm-2021-0113. Epub 2021 Aug 17. PMID: 34402308; PMCID: PMC8411395.
  4. Jun Gao, Min Kyeung Khang, Zhen Liao, Megan Detloff, and Jeoung Soo Lee. Therapeutic targets and nanomaterial-based therapy for mitigation of secondary injury after spinal cord injury. Accepted in Nanomedicine.
  5. Joshua Woo and Jeoung Soo Lee. Effect of lyoprotectants on long-term stability and transfection efficacy of lyophilized poly(lactide-co-glycolide)-graft-polyethylenimine/plasmid DNA polyplexes. Nanomedicine (Lond). 2021 Jun;16(15):1269-1280. doi: 10.2217/nnm-2021-0065. Epub 2021 May 28. PMID: 34044608
  6. Christian Macks, Daun Jeong, Michael Lynn, and Jeoung Soo Lee. Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model. Nanomedicine. 2020 Nov 28:102343. doi: 10.1016/j.nano.2020.102343. Epub ahead of print. PMID: 33259960.
  7. Jeong DU, Bae S, Macks C, Whitaker J, Lynn M, Webb K, Lee JS. Hydrogel-mediated local delivery of dexamethasone reduces neuroinflammation after traumatic brain injury. Biomed Mater. 2020 Nov 5. doi: 10.1088/1748-605X/abc7f1. Epub ahead of print. PMID: 33152711.
  8. Jayesh Betala, Sooneon Bae, Eugene M. Langan III, Martine LaBerge, and Jeoung Soo Lee. "Combinatorial Therapy of Sirolimus and Heparin by Cationic Amphiphilic Nanocarrier Inhibits Restenosis in Porcine Coronary Artery after Balloon Angioplasty ex vivo." Nanomedicine, Published online: Apr 28 2020
  9. Justin Halman, Ki-Taek Kim, So-Jung Gawk, Richard Pace, Morgan B Johnson, Morgan R Chandler, Lauren Rackley, Mathias Viard, Ian Marriott, Jeoung Soo Lee (Co-corresponding author), and Kirill Afonin. "A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (NANPs) for controlled gene silencing, immunostimulation, and biodistribution." Nanomedicine, Nanotechnology, Biology, and Medicine23:102094 (2020).
  10. So-Jung Gwak and Jeoung Soo Lee. "Suicide gene therapy by amphiphilic copolymer nanocarrier for spinal cord tumor." Nanomaterials9(4):573 (2019).
  11. Sooneon Bae, Mike J DiBalsi, Nicole Meilinger, Changzhi Zhang, Beal, Guzylieva Korneva, Robert Brown, Konstantin Kornev, Jeoung Soo Lee. "Heparin-Eluting Electrospun Nanofiber Yarns for Antithrombotic Vascular Sutures." ACS Appl Mater Interfaces14;10(10):8426-8435 (2018)
  12. Jayesh Betala, Jeoung Soo Lee, Eugene M. Langan III, and Martine LaBerge. "Effect of 17-β Estradiol and Iopromide on Rat Primary Smooth Muscle Cell Hyperplastic Response in Static and Dynamic Conditions." Annals of Vascular Medicine and Research 5(2):1088 (2018).
  13. Christian Macks, So-Jung Gwak, Michael Lynn, and Jeoung Soo Lee. "Rolipram-loaded polymeric micelle nanoparticle reduces secondary injury after rat compression spinal cord injury". Journal of Neurotrauma.35:582-592 (2018).
  14. So-Jung Gwak, Christian Macks, Sooneon Bae, Noah Cecil, and Jeoung Soo Lee. "Physicochemical stability and transfection efficiency of cationic amphiphilic copolymer/pDNA polyplexes for spinal cord injury repair". Scientific Report. 7(1):11247. (2017).
  15. So-Jung Gwak, Christian Macks, Da Un Jeong, Mark Kindy, Michael Lynn, Ken Webb, Jeoung Soo Lee. "RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model." Biomaterials. 121: 155–166 (2017).
  16. Jeremy Zhang, Jeoung Soo Lee, Atanu Sen, Eunhee Cho, and Ken Webb. "Poloxamine/fibrin hybrid hydrogels for non-viral gene delivery."Journal of Tissue Engineering and Regenerative Medicine. 11(1): 246-255 (2017).
  17. Chritian Macks and Jeoung Soo Lee. "Non-viral vector mediated RNA Interference Technology for Central Nerve System Injury," Mini-review. Accepted in DNA and RNA Nanotechnology. (June 2016).
  18. So Jung Gwak, Justin Nice, Jeremy Zhang, Benjamin Green, Christian Macks, Sooneon Bae, and Ken Webb, and Jeoung Soo Lee. "Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord." Acta Biomaterialia. 35: 98-108 (2016).
  19. Sooneon Bae, Ho Joon Lee, Jeoung Soo Lee, and Ken Webb. "Cell-Mediated Dexamethasone Release from Semi-IPNs Stimulates Osteogenic Differentiation of Encapsulated Mesenchymal Stem Cells." Biomacromolecules. 16(9):2757-65 (2015).
  20. Ho Joon Lee, Sooneon Bae, Atanu Seng, Jeoung Soo Lee, and Ken Webb. "PEG-diacrylate/hyaluronic acid semi-interpenetrating network compositions for 3D cell spreading and migration." Acta Biomaterialia 14:43-52 (2015).
  21. Jeremy Zhang, Sooneon, Bae, Jeoung Soo Lee, and Ken Webb. "Efficacy and mechanism of poloxamine-assisted polyplex transfection". J Gene Medicine. 15 (8-9): 271-281 (2013).
  22. Jeremy Zhang, Justin Nice, So Jung Gwak, Benjamin green, Ken Webb, and Jeoung Soo Lee. "Target-specific polymeric micelle as a nucleic acid delivery carrier for neuronal regeneration in central nervous system" (manuscript in preparation).
  23. So Jung Gwak, Justin Nice, Benjamin green, Christian Macks, and Jeoung Soo Lee. "Multi-functional polymeric micelle delivery carrier for spinal cord tumor" (manuscript in preparation).
  24. Wayne Reeder, Jessica Lau, Lesly Temesvari, and Jeoung Soo Lee. "Novel Colon-specific Bi-functional Polymeric Prodrugs for the Treatment of Amebiasis" (manuscript in preparation).
  25. Eunhee Cho, Jeoung Soo Lee, and Ken Webb. "Formulation and characterization of poloxamine-based hydrogels as tissue sealants." Acta Biomater. Jul 8(6): 2223-32 (2012).
  26. Eunhee Cho, Jaishankar K. Kutty, Kedar Datar, Jeoung Soo Lee, Naren R. Vyavahare and Ken Webb. "A Novel Synthetic Route for the Preparation of Hydrolytically Degradable Synthetic Hydrogels."JBMR (Part A), 90 (4): 1073-1082 (2009).
  27. Rebecca C Cribb, F. T. Haddadin, Jeoung Soo Lee, and Ken Webb. "Baculovirus Expression and Bioactivity of a Soluble 140 kDa Extracellular Cleavage Fragment of L1 Neural Cell Adhesion Molecule." Protein Expression and Purification. 57 (2): 172-179 (2008).
  28. Jaishankar K Kutty, Eunhee Cho, Jeoung Soo Lee, Naren R. Vyavahare, and Ken Webb. "The effect of hyaluronic acid incorporation on fibroblast spreading and proliferation within PEG-diacrylate based semi-interpenetrating networks." Biomaterials 28: 4928-38 (2007).
  29. Jeoung Soo Lee, Joo Hyeun Rho, Young Wook Yang, Hae sik Kong, and Young Mi Kim. "Synthesis and in vitro evaluation of N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil."J Drug Target 15(3): 199-205 (2007).
  30. Jeoung Soo Lee, Young Wook Yang, Inho Kim, Yun Jin Jung, and Young Mi Kim. "Synthesis and properties of N-nicotinoyl-2-(5-fluorouracil-1-yl)-D,L-glycine ester as a prodrug of 5-fluorouracil for rectal administration."Eur J Pharm Biopharm. 66(2): 260-267. (2007).
  31. Jeoung Soo Lee, Dina M. Basalyga, Agneta Simionescu, Jason C. Isenburg, Dan T. Simionescu, and Narendra R. Vyavahare. "Elastin calcification in the rat subdermal model is accompanied by upregulation of degradative and osteogenic cellular responses". Am J. Pathol, 168 (2): 490-498 (2006).
  32. Dan T. Simionescu, Quijin Lu, Ying Song , Jeoung Soo Lee, TN Rosenbalm, C Kelly, and Naren Vyavahare. "Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds". Biomaterials, 27(5): 702-713 (2006).
  33. Jeoung Soo Lee, Minhyung Lee, and Sung Wan Kim. "A New Potent hFIX Plasmid for Hemophilia B Gene Therapy." Pharm. Res., 21 (7): 1229-1232 (2004).
  34. Yun Jin Jung, Minju Doh, Haesik Kong, Jeoung Soo Lee and Young Mi Kim."Prednisolone 21-sulfate sodium: a colon-specific pro-drug of prednisolone".J Pharm Pharmacology, 55 (8): 1075-1082 (2003).
  35. Yun Jin Jung, Jeoung Soo Lee and Young Mi Kim. "Colon-specific Prodrug of 5-Aminosalicylic acid: Synthesis and In Vitro/In Vivo Properties of Acidic Amino acid Derivatives of 5-Aminosalicylic acid". J. Pharm.Sci., 90 (11): 1767-1775 (2001).
  36. Seong-Wan Cho, Jeoung Soo Lee, and Seung-Ho Choi. "Enhanced oral bioavailability of poorly absorbed drugs. I Screening of absorption carrier for the ceftriaxone complex." J. Pharm. Sci., 93(3): 612-20 (2004).
  37. Jeoung Soo Lee, and SungWan Kim. Synthesis and Characterization of Biodegradable Mixed Polymeric Micelle for Gene Delivery. Twenty ninth Annual meeting of the Controlled Release Society, Seoul Korea, July (2002).
  38. Jeoung Soo Lee, and SungWan Kim. Biodegradable Mixed Polymeric Micelles as A Carrier for Targeting Genes into Hepatocytes. The American Society of Gene Therapy’s 5th Annual Meeting, Boston, June (2002).
  39. Jeoung Soo Lee, SeungHo Choi, and SungWan Kim. Improvement of Oral Absorption of Ceftriaxone using bioadhesive polymers. Tenth International Symposium on recent Advences in Drug Delivery Systems, 145-146 (2001).
  40. Jeoung Soo Lee, Yun Jin Jung, Minju Doh, and Young Mi Kim. "Synthesis and Properties of Dextran-Nalidixic acid Ester as a Colon-specific Prodrug of Nalidixic acid".Drug Dev Ind Pharm., 27(4): 331-336 (2001).
  41. Jeoung Soo Lee, Yun Jin Jung, Hak Hyun Kim, and Young Mi Kim. "Synthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil."J. Pharm. Sci., 90 (11): 1787-1794 (2001).
  42. Yun Jin Jung, Jeoung Soo Lee and Young Mi Kim. "Synthesis and In Vitro/In Vivo Evaluation of 5-Aminosalicyl-Glycine as a Colon-specific Prodrug of 5-Aminosalicylic acid." J. Pharm.Sci., 89 (5): 594-602 (2000).
  43. Jeoung Soo Lee, Yun Jin Jung, Youn Taeg Kim, Young Mi Kim. "Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Metronidazole Complex."Textile Res. J., 70 (7): 641-645 (2000).
  44. Jeoung Soo Lee, Yun Jin Jung, Min Ju Doh and Young Mi Kim. "Cotton Fabrics with Prolonged Antibacterial Activity: Formation, Properties of Cotton Xanthate-Al(III)-Tetracycline Complex."J. Bioac. and Comp. Pol., 15 (5): 425-437 (2000).
  45. Yun Jin Jung, Jeoung Soo Lee, Yun Taek Kim, Young Mi Kim and Suk Kyu Han. "Synthesis and Evaluation of 5-Aminosalicyl-glycine as a Potential Colon-specific Prodrug of 5-Aminosalicylic acid."Arch. Pharm. Res., 21(2): 174-178 (1998).
  46. Yun Jin Jung, Jeoung Soo Lee, Hak Hyun Kim, Young Mi Kim, and Suk Kyu Han. "Synthesis and Properties of 5-Aminosalicyl-L-Aspartic Acid and 5-Aminosalicyl-L-Glutamic Acid as Colon-specific Prodrugs of 5-Aminosalicylic Acid." Yakhak Hoeji, 42(1): 5-11 (1998).
  47. Young Mi Kim, Neung Jin Ha, Yun Jin Jung, and Jeoung Soo Lee. "Formation and Properties of Cotton Xanthate-Mg(II)-Homosulfamine Complex."Pusan Bulletin of Pharmaceutical Sciences, 33, 9-13 (1999).
  48. Yun Jin Jung, Jeoung Soo Lee, Hak Hyun Kim, Young Mi Kim, and Suk Kyu Han. "Dextran-5-(4-Ethoxycarbonylphenylazo) Salicylic Acid Ester as a Colon-specific Prodrug of 5-Aminosalicylic Acid."Yakhak Hoeji, 42(1): 31-38 (1998).
  49. Yun Jin Jung, Jeoung Soo Lee, Yun Taek Kim, Young Mi Kim. "Synthesis and Properties of Dextran-5-Aminosalicylic Acid as a Potential Colon-specific Prodrug of 5-Aminosalicylic acid."Arch. Pharm. Res., 21(2): 179-186 (1998).
  50. Neung Jin Ha, Yun Jin Jung, Jeoung Soo Lee, Youn Taeg Kim and Young Mi Kim. "Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Homosulfamine Complex."Arch. Pharm. Res., 21(5): 570-575 (1998).
  51. Neung Jin Ha, Yun Jin Jung, Jeoung Soo Lee, Youn Taeg Kim, Young Mi Kim, Sung Cheul Hong, Suk Kyu Han. "Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Zn(II)-Homosulfamine Complex."Pusan Bulletin of Pharmaceutical Sciences 31(1): 13-19 (1997).
  52. Jeoung Soo Lee, Youn Taeg Kim, Yun Jin Jung, Young Mi Kim, and Bok Ruel Lee, and Won Jae Cho. "Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Tetracycline Complex." Pusan Bulletin of Pharmaceutical Sciences, 30(1):11-17 (1996).
  53. Youn Taeg Kim, Yun Jin Jung, Jeoung Soo Lee and Young Mi Kim, "Formation and Antimicrobial Activities of Chitosan-Zn(II)-Tetracycline Complex." Pusan Bulletin of Pharmaceutical Sciences, 31(1): 5-10 (1996).
  54. Youn Taeg Kim, Jong Ho Yu, Yun Jin Jung, Jeoung Soo Lee and Young Mi Kim. "Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Mg(II)-Tetracycline Complex."Yakhak Hoeji, 39(4): 373-379 (1995).
  55. Yun Taek Kim, Young Mi Kim, Yun Jin Jung, Jeoung Soo Lee. "Formation and Antimicrobial Activities of Chitosan-Cu(II)-Tetracycline Complex." Pusan Bulletin of Pharmaceutical Sciences, 28(2): 29-34 (1994).
  56. Jeoung Soo Lee, Yun Jin Jung, Youn Taeg Kim, and Young Mi Kim, Preparation and Antimicrobial Activities of Cotton Xanthate-Metal-Oxine Complex. Pusan Bulletin of Pharmaceutical Sciences, 27(2): 1-7 (1993).

Book Chapters

  1. K. Webb and J. S. Lee. "Molecular analysis in mechanobiology." In: J. Nagatomi, editor, Mechanobiology Handbook. Boca Raton: CRC Press, 2011, p. 45-72. (Introduction)

Conference Proceedings

  1. Zhen Liao, Jun Gao, Min Kyung Khang, Megan Ryan Detloff, and Jeoung Soo Lee, Rolipram delivered by PgP nanocarrier enhances motor function in a rat moderate contusion SCI model. Presented in National Neurotrauma Society 2022 annual meeting, Atlanta, GA
  2. Claire E. Jones, Bradley Elliott, Fuying Ma, Zack Johnson, Zhen Liao, Zachary Bailey, Janice Gilsdorf, Anke Scultetus, Deborah Shear, Ken Webb, and Jeoung Soo Lee, PEG based HA-Dexamethasone hydrogel reduced inflammatory response and improves motor and cognitive function in a rat moderate controlled cortical impact (CCI) TBI model. Presented in National Neurotrauma Society 2022 annual meeting, Atlanta, GA
  3. Zhen Liao, Jun Gao, Min Kyung Khang, Megan Ryan Detloff, and Jeoung Soo Lee, Rolipram delivered by PgP nanocarrier enhances motor function and reduces neuropathic pain in a rat contusion SCI model. Presented in18th International Symposium on Recent Advances in Drug Delivery Systems, SLC, UT
  4. Christian Macks, Daun Jeong, Sooneon Bae, Ken Webb, and Jeoung Soo Lee, Local application of biodegradable dexamethasone-loaded hydrogel improves motor and cognitive functional recovery of after traumatic brain injury in rats. Presented in 18th International Symposium on Recent Advances in Drug Delivery Systems, SLC, UT
  5. Claire E. Jones, Jeoung Soo Lee, and Teresa A. Murray, Rolipram complexed with the PgP nanocarrier reduced secondary inflammation after murine brain injury, National Neurotrauma Society, 2021 virtual meeting
  6. Jun Gao, Min Kyeung Khang, Zhen Liao, Megan Detloff, and Jeoung Soo Lee. Rolipram delivered by PgP nanocarrier enchances motor function recovery in a rat moderate contusion SCI model. Presented in Society for Neuroscience 2021 virtual annual meeting.
  7. Daun Jeong, Sooneon Bae, Christian Macks, Joseph Whitaker, Michael Lynn, Ken Webb, and Jeoung Soo Lee, Local Delivery of Dexamethasone by Hydrogel Reduces Secondary Injury and Promote Motor Function after Traumatic Brain Injury, National Capital Area, Traumatic Brain Injury 2020 Symposium, Washington DC, Mar 2020
  8. Christian Macks, Da Un Jeong, Michael Lynn, and Jeoung Soo Lee, Cyclic AMP restoration by rolipram- loaded nanocarrier reduces secondary injury after traumatic brain injury, National Capital Area, Traumatic Brain Injury 2020 Symposium, Washington DC, Mar 2020
  9. Christian Macks, Da Un Jeong, Michael Lynn, and Jeoung Soo Lee, RhoA knockdown by PgP/siRhoA nanopolyplex enhances traumatic brain injury repair, Southeast Regional IDeA Conference 2019, Lexington, KY 
  10. So-Jung Gwak, Christian Macks, Ken Webb, Michael Lynn, Mark Kindy and Jeoung Soo Lee. Rolipram and RhoA siRNA combinatorial by PgP Nanoparticle Increases Functional Recovery in a Rat Contusion Spinal Cord Injury Model, Southeast Regional IDeA Conference 2019, Lexington, KY 
  11. Ki-Taek Kim, Justin Halman, Christian Macks, Kirill Afonin, and Jeoung Soo Lee. Blood compatibility and biodistribution of various PgP/nucleic acid polyplex nanoparticles in vivo, Southeast Regional IDeA Conference 2019, Lexington, KY 
  12. Christian Macks, Daun Jeong, Michael Lynn, Mark Kindy, and Jeoung Soo Lee, RhoA siRNA local delivery by pgp nanocarrier reduces secondary injury after traumatic brain injury,  Society for Neuroscience 2019 meeting, Chicago, IL, 2019
  13. Christian Macks, Daun Jeong, Michael Lynn, Mark Kindy, and Jeoung Soo Lee, Local delivery of Rolipram using PgP  nanocarrier reduces secondary injury after traumatic brain injury, Society for Neuroscience 2019 meeting, Chicago, IL, 2019
  14. David Oglesby, Wendy Cornett, and Jeoung Soo Lee, Combinatorial Therapy of siMDR1 and Doxorubicin to Mediate Drug Resistance in Breast Cancer Models, Society for Biomaterials, Seattle, Washington, Apr 2019
  15. Christian Macks, DaUn Jeong, Michael Lynn, and Jeoung Soo Lee,  Rm-loaded polymeric micelle reduces secondary injury in a rat TBI model, Society for Biomaterials, Seattle, Washington, Apr 2019
  16. Kitaek Kim, Justin Halman, Christian Macks, Kirill Afonin, and Jeoung Soo Lee, Blood compatibility and biodistribution of various therapeutic nucleic acid (TNA) polyplexes, Society for Biomaterials, Seattle, Washington, Apr 2019
  17. Joshua Woo, Kitaek Kim, Christian Macks, and Jeoung Soo Lee, Characterization of Long-term stability of PgP/pGFP Polyplexes with Varying Cryoprotectants, Society for Biomaterials, Seattle, Washington, Apr 2019
  18. Andrew DeMaria, Jeoung Soo Lee, and Ken Webb. “N-oxalylglycine-conjugated hyaluronic acid stimulates angiogenic gene expression, Society for Biomaterials, Seattle, WA (2019).
  19. Christian Macks, DaUn Jeong, Michael Lynn, and Jeoung Soo Lee, Rolipram and RhoA siRNA local delivery by nanocarrier reduces inflammatory response and apoptosis after traumatic brain injury, Wallace R. Roy Functional Radiology Symposium, Mar 2019
  20. Claire E. Jones, Chelsea D. Pernic, Jeoung Soo Lee,  and Teresa A. Murray, Nanoparticle Delivery of Therapeutics to Treat Traumatic Brain Injury, Wallace R. Roy Functional Radiology Symposium, Mar 2019
  21. So-Jung Gwak, Christian Macks, Michael Lynn, Mark Kindy, Ken Webb, and Jeoung Soo Lee, Rolipram and RhoA siRNA local delivery by nanocarrier reduces secondary injury and enhances axon regeneration in a rat compression injury model, Wallace R. Roy Functional Radiology Symposium, Mar 2019
  22. So-Jung Gwak, Christia Macks,  Jin Yu, Hong Zhu, Michael Lynn, Ken Webb, Mark Kindy, and Jeoung Soo Lee, Combinatorial Treatment of Rolipram and RhoA siRNA delivered by PgP nanoparticle Increases Function recovery in a  Rat Contusion Spinal Cord Injury, in Society for Neuroscience 2018 meeting, San Diego, CA, Oct 2018
  23. Christian Macks, DaUn Jeong, So-Jung Gwak, Michael Lynn, and Jeoung Soo Lee, RhoA knockdown by PgP/siRhoA polyplexes reduces secondary injury in a rat TBI model, in Society for Biomaterials 2018 meeting, Atlanta, GA, Apr 2018
  24. Andrew DeMaria, Jeoung Soo Lee, and Ken Webb. “Development on N-oxalylglycine-conjugated hyaluronic acid for therapeutic angiogenesis”, Society for Biomaterials, Atlanta, GA , Apr 2018
  25. So-Jung Gwak, Christian Macks, Da Un Jeong, Michael Lynn, Ken Webb, and Jeoung Soo Lee, Cationic amphiphilic polymeric micelle as therapeutic siRhoA carrier for Axonal Regeneration in spinal cord injury, SFB 2017 annual meeting, Minneapolis, MI, Apr 2017
  26. Da Un Jeong, Sooneon Bae, Christian Macks, Joseph Whitaker, Michael Lynn, Ken Webb, and Jeoung Soo Lee, Anti-inflammatory Effects of PEG-bis-AA/HA-DXM hydrogel in Rat Traumatic Brain Injury, Accepted in SFB 2017 annual meeting, Minneapolis, MI, Apr 2017
  27. So-Jung Gwak, Christian Macks, Ken Webb, Michael Lynn, and Jeoung Soo Lee, RhoA Knockdown by PgP/RhoA siRNA Nanoparticle Increases Axon Growth after rat spinal cord injury, Accepted as poster in Society for Neuroscience (SFN) 2016 annual meeting
  28. Christian Macks, So-Jung Gwak, Michael Lynn, and Jeoung Soo Lee, The effect of rolipram-loaded polymeric micelle nanoparticle on cAMP level in hypoxia condition and in rat SCI model, Biomaterials Symposium in Rutgers Biomaterials Center, 2016
  29. So-Jung Gwak, Christian Macks, Ken Webb, Michael Lynn, and Jeoung Soo Lee, Cationic amphiphilic copolymer as a RhoA siRNA carrier for axonal regeneration in rat spinal cord injury, Biomaterials Symposium in Rutgers Biomaterials Center, 2016
  30. So-Jung Gwak, Christian Macks, Ken Webb, Michael Lynn, Mark Kindy and Jeoung Soo Lee, Cationic Polymeric Micelle as a RhoA siRNA Carrier for Axonal Regeneration in rat compression SCI model, Military Health System Research Symposium (MHSRS), 2016, Orlando, FL
  31. Christian Macks, So-Jung Gwak, Ken Webb, Michael Lynn, and Jeoung Soo Lee, Combinatorial Therapy of Rolipram and pNGF for Traumatic Brain Injury, Military Health System Research Symposium (MHSRS), 2016, Orlando, FL
  32. Angela A. Alexander-Bryant and Jeoung Soo Lee, Nanotherapeutics for combinatorial drug and gene therapy in treating glioblastoma multiforme, BMES 2016 annual meeting, Minneapolis, MI
  33. So-Jung Gwak, Christian Macks, Ken Webb, Michael Lynn, Mark Kindy, and Jeoung Soo Lee, PolymericMicelle as therapeutic siRNA carrier for Axonal Regeneration in spinal cord injury, 10th World Biomaterials Congress 2016, Montreal, Canada
  34. Graham Temples, Jeoung Soo Lee, Folate-functionalized Polymeric Micelle for Combinatorial Therapy to Overcome Drug Resistant Breast Cancer, Society for Biomaterials annual meeting, Charlotte, NC, 2015
  35. Michael DiBalsi1, Sooneon Bae1, Guzeliya Korneva1, Konstantin G. Kornev2, and Jeoung Soo Lee1, Heparin-eluting Vascular Suture for Preventing Thrombosis and Stenosis, Society for Biomaterials annual meeting, Charlotte, NC, 2015
  36. So-Jung Gwak, Ben Green, Christian Macks, and Jeoung Soo Lee Polymeric Micelle as a Nucleic Acid Carrier for Axonal Regeneration in CNS, Society for Biomaterials annual meeting, Charlotte, NC, 2015
  37. Christian Macks, So Jung Gwak, Graham Temples, Guzeliya Korneva, and Jeoung Soo Lee, Combinatorial Therapy of Rolipram and pNGF for Traumatic Brain Injury, Society for Biomaterials 2015 annual meeting, Charlotte, NC, 2015
  38. Ben Green, So-Jung Gwak, Graham Temples, and Jeoung Soo Lee, Polymeric micelle as a drug and gene delivery carrier for brain tumor, Society for Biomaterials 2015 annual meeting, Charlotte, NC, 2015
  39. Soon Eon Bae, Jeoung Soo Lee, Jeremy L Barth, and Ken Webb, Vibratory stimulation for anti-fibrotic therapy” Society for Biomaterials, Charlotte, NC, 2015
  40. So-Jung Gwak, Justin Nice, Ben Green, Christian Macks, and Jeoung Soo Lee, Polymeric Micelle as a Drug and Gene Delivery Carrier for Spinal Cord Tumor, BMES 2014 annual meeting, San Antonio, TX, 2014
  41. Jayesh Betala, JeoungSoo Lee , Eugene Langan, Martine LaBerge, Effects Of Short-term Exposure of Estrogen On Smooth Muscle Cells Proliferation, BMES 2014 annual meeting, San Antonio, TX, 2014
  42. Michael DiBalsi, Sooneon Bae, Guzeliya Korneva1, Konstantin G. Kornev2, and Jeoung Soo Lee, Heparin-immobilized Electrospun Nanofibers for Vascular Sutures, 5th Biennial NIH, NCRR National IDeA Symposium of Biomedical Research Excellence (NISBRE),Washington DC, 2014
  43. Graham Temples, Justin Nice, and Jeoung Soo Lee, Folate-mediated polymeric micelle delivery system for Drug Resistant Cancer, 5th Biennial NIH, NCRR National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington DC, 2014
  44. So-Jung Gwak, Justin Nice, Ben Green, Christian Macks, and Jeoung Soo Lee, Polymeric micelle as a drug and gene delivery carrier for spinal cord tumor, 5th Biennial NIH, NCRR National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington DC, 2014
  45. Justin Nice, So Jung Gwak, Ken Webb, and Jeoung Soo Lee, Polymeric micelle as a combinatorial delivery system for central nervous system regeneration, 5th Biennial NIH, NCRR National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington DC, 2014
  46. Graham Temples, Justin Nice, Ben Green, and Jeoung Soo Lee, Multi-functional Polymeric Micelle Delivery System for Drug Resistant Cancer Treatment, Society for Biomaterials annual meeting, Denver, CO (2014)
  47. Justin Nice, Graham Temples, Ken Webb, and Jeoung Soo Lee, Polymeric Micelle Delivery System for Neural Regeneration, Society for Biomaterials annual meeting, Denver, CO (2014)
  48. Michael DiBalsi, Sooneon Bae, Guzeliya Korneva, Konstantin G. Kornev, and Jeoung Soo Lee, Heparin-immobilized Electrospun Nanofibers for Vascular Sutures, Society for Biomaterials annual meeting, Denver, CO (2014)
  49. Sooneon Bae, Ho-Joon Lee, Jeoung Soo Lee, Ken Webb, Osteogenic Differentiation of Encapsulated Mesenchymal Stem Cells in Dexamethasone-Functionalized Semi-IPN Hydrogels, Society for Biomaterials annual meeting, Denver, CO (2014)
  50. Atanu Sen, Thuy Le, Ho-Joon Lee, Kathryn Stevens, Jeoung Soo Lee, Ken Webb, Fiber-based microcarriers for enhanced proliferation of hydrogel-encapsulated cells, Society for Biomaterials annual meeting, Denver, CO (2014)
  51. Ho Joon Lee, Sooneon Bae, Jeoung Soo Lee, Ken Webb Osteogenic differentiation of hMSC in PEG diacrylate/hyaluronic acid semi-IPNs, Society for Biomaterials annual meeting, Denver, CO (2014)
  52. Graham Temples, Ben Green, Justin Nice, and Jeoung Soo Lee, Multi-functional Polymeric Micelle Delivery System for Drug Resistant Cancer Treatment, Biomaterials Day, Clemson, SC (2013)
  53. Justin Nice, Graham Temples, Ken Webb, and Jeoung Soo Lee, Polymeric Micelle Delivery System for Neural Regeneration, Biomaterials, Clemson, SC (2013)
  54. Michael DiBalsi1, Sooneon Bae1, Guzeliya Korneva1, Konstantin G.Kornev2, and Jeoung Soo Lee, Characterization of Heparin-immobilized Electrospun Nanofibers, Biomaterials Day, Clemson, SC (2013)
  55. Jeoung Soo Lee, Wayne Reeder, Jessica Lau, Thomas Reed, and Lesly Temesvari. Effect of Colon-specific Prodrugs on the amoeba-host cell interaction. BMES 2012 Annual meeting, Atlanta, GA (2012)
  56. Jeremy Zhang, Atanu Sen, Eunhee Cho, Jeoung Soo Lee, and Ken Webb. Hybrid T904/Fibrinogen Hydrogels for sustained non-viral gene delivery. Biomedical Engineering Society Annual Meeting, Atlanta, GA (2012)
  57. J. Zhang, A. Walker, J. S. Lee, K. Webb. Tetronic® T904 increases transfection efficiency of polyplex nonviral vectors. Biomedical Engineering Society Annual Meeting, Atlanta, GA (2012)
  58. HoJoon Lee, Atanu Sen, Jeoung Soo Lee, and Ken Webb, Effect of network composition on cellular remodeling of PEG diacrylate / hyaluronic acid semi-IPNs. Biomedical Engineering Society Annual Meeting, Atlanta, GA (2012)
  59. Soon Eon Bae, Jeoung Soo Lee, Jeremy Barth, and Ken Webb. The effect of Variable Vibratory Stimulation on Fibroblast Matrix –related Gene Expression. Biomedical Engineering Society Annual Meeting, Atlanta, GA (2012)
  60. Jeoung Soo Lee, Wayne Reeder, Don Mackay, Kangmin Lee, Lesly Temesvari, Yunjin Jung, and Young Mi Kim. Novel Colon-specific Bi-functional Polymeric Prodrugs for the Treatment of Amebiasis. American Association of Pharmaceutical Scientists 25th Annual Meeting and Exposition, Washington, DC (2011)
  61. J. Zhang, A. Sen, E. Cho, J. S. Lee, and K. Webb. "Biosynthetic hydrogels for gene delivery." Southeastern Regional IdEA Meeting, New Orleans, LA (2011)
  62. A. Sen, R. C. Cribb, J. S. Lee, and K. Webb. "Covalent immobilization and bioactivity of fibronectin in Tetronic hydrogels." Southeastern Regional IdEA Meeting, New Orleans, LA (2011)
  63. Jeremy Zhang, Ken Webb, and Jeoung Soo Lee. Neuron-specific Polymeric Micelle as a siRNA Delivery Carrier for CNS. Society for Biomaterials Annual Meeting, Florida, OL (2011)
  64. Jeremy Zhang, Atanu Sen, Eunhee Cho, Jeoung Soo Lee, and Ken Webb. Nonviral Vector Delivery from T904/Fibrinogen Hydrogels. Society for Biomaterials Annual Meeting, Florida, OL (2011)
  65. Atanu Sen, Rebecca C. Cribb, Jeoung Soo Lee, Ken Webb. Bulk and Surface Covalent Immobilization of Molecules on Hydrogel Formed by Micheal –type Addition. Society for Biomaterials Annual Meeting, Florida, OL (2011)
  66. Ho-Joon Lee, Eunhee Cho, Carlyn Sander, Derick Burgin, Elizabeth Steele, Atanu Sen, Jeoung Soo Lee, Ken Webb. Fabrication and Characterization of Synthetic Hydrogel Fibers. Society for Biomaterials Annual Meeting, Florida, OL (2011)
  67. Brad Winn, Vipul Taneja, Alexey Vertegel, Eugene M. Langan III, Jeoung Soo Lee, Martine LaBerge. Influence of Topography of Endovascular Stent Material on Smooth Muscle Cell Response. Society for Biomaterials Annual Meeting, Florida, OL (2011)
  68. Jeoung Soo Lee, Jeremy Zhang, and Ken Webb. Neuron-specific Polymeric micelle nanotherapeutics for CNS regeneration. Society for Biomaterials Annual Meeting, Seattle, WA (2010)
  69. Eunhee Cho, Jiro Nagatomi, Jeoung Soo Lee, and Ken Webb. Bioactive bladder tissue adhesive. Society for Biomaterials, San Antonio, TX (2009)
  70. Jeoung Soo Lee, Rebecca C. Cribb, Eunhee Cho, Jaishanchar Kutty, and Ken Webb. Synthesis and Characterization of di-Functional PEG-based Crosslinkers for L1 Immobilization. Society for Biomaterials Annual Meeting, Chicago (2007)
  71. J. K. Kutty, E. H. Cho, J. S. Lee, and K. Webb. Polyethylene glycol diacrylate / hyaluronic acid semi-IPNs support increased cell spreading and proliferation. " Transactions of the 32nd Annual Meeting of the Society for Biomaterials, page 652 (2007)
  72. Rebecca C. Cribb, Jeoung Soo Lee, and Ken. Webb. Cloning and expression of bioactive recombinant L1 neural cell adhesion molecule. Regenerate World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA (2006)
  73. Jeoung Soo Lee, Dina M. Basalyga, Agneta Simionescu, Dan T. Simionescu, and Narendra R. Vyavahare, Osteogenic and Matrix Remodeling Gene Expression Associated with Elastin Calcification. Society for Biomaterial Annal Meeting, Memphis, May (2005)
  74. Kedar Datar, Jeoung Soo Lee, Naren. Vyavahare, and Ken Webb, Controlled release hydrogel coatings on deep groove polymer fibers for spinal cord regeneration. Society for Biomaterials, Memphis, TN (2005)
  75. Jeoung Soo Lee, and Sung Wan Kim. Biodegradable Mixed Polymeric Micelles as A Carrier for Targeting Genes into Hepatocytes. The American Society of Gene Therapy's 5th Annual Meeting, Boston, June (2002)
  76. Jeoung Soo Lee, and Sung Wan Kim. Synthesis and Characterization of Biodegradable Mixed Polymeric Micelle for Gene Delivery. Twenty ninth Annual meeting of the Controlled Release Society, Seoul Korea, July (2002)
  77. Jeoung Soo Lee, SeungHo Choi, and SungWan Kim. Improvement of Oral Absorption of Ceftriaxone using bioadhesive polymers. Tenth International Symposium on recent Advences in Drug Delivery Systems, Salt Lake City, Febrary (2001)
  78. Jeoung Soo Lee, Yun Jin Jung, Minju Doh, and Young Mi Kim, Synthesis and Properties of N-Nicotinyl-2-(5-Fluorouracil-1-yl)-D,L-Glycine Esters to Improve Rectal Absorption of 5-Fluorouracil. American Association of Pharmaceutical Scientists, Indianapolis, October (2000)
  79. Jeoung Soo Lee, SeungHo Choi, and SungWan Kim. Screening of Various Complexes to Improve Oral Absorption of Ceftriaxone, the Third Generation Cephalosporin. American Association of Pharmaceutical Scientists, Indianapolis, October (2000)
  80. Jeoung Soo Lee,Yun Jin Jung, Minju Doh, and Young Mi Kim, Synthesis and Properties of Dextran-Nalidixic acid Ester as a Colon-specific Prodrug of Nalidixic acid. American Association of Pharmaceutical Scientists, Indianapolis, October (2000)
  81. Jeoung Soo Lee, SungWan Kim, D.J. Hoban, and SeungHo Choi, Pharmacokinetic study of Complexes to Improve Oral Absorption of Third Generation Cephalosporins. The Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, September (2000)
  82. Jeoung Soo Lee,Yun Jin Jung, Hak Hyun Kim, and Young Mi Kim, Development of a Colon-specific Prodrug of 5-Fluorouracil: Synthesis and Properties of N-Nicotinyl-2-(5-Fluorouracil-1-yl)-D,L-Glycine. American Association of Pharmaceutical Scientists, New Orleans, November (1999)
  83. Jeoung Soo Lee,Yun Jin Jung, Hak Hyun Kim, and Young Mi Kim, Development of a Colon-specific Prodrug of 5-Fluorouracil: Synthesis and Properties of N-Nicotinylglycyl-2-(5-Fluorouracil-1-yl)-D,L-Glycine. American Association of Pharmaceutical Scientists, New Orleans, November (1999)
  84. Yun Jin Jung, Hak Hyun Kim, Jeoung Soo Lee and Young Mi Kim, Synthesis and in vitro/in vivo Evaluation of N,N-Bis(5-Aminosalicyl)-L-Cystine as a Colon-specific Prodrug of 5-Aminosalicylic Acid. American Association of Pharmaceutical Scientists, New Orlence, November (1999)
  85. Jeoung Soo Lee, Ju Hyun Noh and Young Mi Kim, Synthesis and Properties of N-Nicotinyl-2-(5-Fluorouracil-1-yl)-D,L-Glycine Esters. The Spring Convention of The Pharmaceutical Society of Korea, Pusan, April (1999)
  86. Yun Jin Jung, Hak Hyun Kim, Jeoung Soo Lee and Young Mi Kim, Synthesis and in vitro/in vivo Evaluation of 5-Aminosalicyl-Amino Acid as a Potential Colon-specific Prodrug of 5-Aminosalicylic Acid: 5-Aminosalicyl-Aspartic Acid and 5-Aminosalicyl-Glutamic Acid. American Association of Pharmaceutical Scientists, San Francisco, November (1998)
  87. Yun Jin Jung, Hak Hyun Kim, Jeoung Soo Lee and Young Mi Kim, Synthesis and in vitro/in vivo Evaluation of 5-Aminosalicyl-Amino Acid as a Potential Colon-specific Prodrug of 5-Aminosalicylic Acid: 5-Aminosalicyl-Glycine. American Association of Pharmaceutical Scientists, San Francisco, November (1998)
  88. Jeoung Soo Lee, Yun Jin Jung, Hak Hyun Kim, Young Mi Kim, and Suk Kyu Han Development of Colon-specific Prodrugs of 5-Fluorouracil : Synthesis and Properties of N-Nicotinyl-2-(5-Fluorouracil-1-yl)-D,L-Glycine. The Spring Convention of The Pharmaceutics Society of Korea, Pusan, April (1998)
  89. Hak Hynu Kim. Yun Jin Jung, Jeoung Soo Lee, Ju Heun Noh, and Young Mi Kim, Development of colon-specific prodrug of 5-Aminosalicylic Acid : Synthesis and properties of 5-Aminosalicyl-taurine. The Spring Convention of The Pharmaceutical Society of Korea, Pusan, April (1998)
  90. Jeoung Soo Lee, Yun Jin Jung, Hak Hynu Kim, and Young Mi Kim, Development of Colon-specific Prodrugs of 5-Fluorouracil: Synthesis and Properties of N-Acyl-2-(5-Fluorouracil-1-yl)- D,L-Glycine. The 47th Annual Convention of The Pharmaceutical Society of Korea, Soowon, October (1998)
  91. Hak Hyun Kim, Yun Jin Jung, Jeoung Soo Lee and Young Mi Kim, Development of Colon-specific Prodrugs of 5-Aminosalicylic Acid: Synthesis and Properties of 5-Aminosalicyl-L-Cysteine. The 47th Annual Convention of The Pharmaceutical Society of Korea, Soowon, October (1998)
  92. Jeoung Soo Lee, Yun Jin Jung, Soo Hee Moon, Youn Taek Kim, and Young Mi Kim, Formation and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Metronidazole Complex. The Spring Convention of The Pharmaceutical Society of Korea, Daegu, April (1997)
  93. Yun Jin Jung, Jeoung Soo Lee, Hak Hyun Kim. Young Mi Kim and Suk Kyu Han, Development of Colon-specific Prodrugs: Synthesis and Properties of Dextran-5-(4-Ethoxy carbonylphenylazo) Salicylic Acid Ester. The Spring Convention of The Pharmaceutical Society of Korea, Daegu, April (1997)
  94. Yun Jin Jung, Jeoung Soo Lee, Hak Hyun Kim. Young Mi Kim and Suk Kyu Han, Synthesis and Properties of Colon-specific 5-Aminosalicylic Acid Prodrugs Utilizing Amino Acid as Carriers. The 46th annual Convention of The Pharmaceutical Society of Korea, Seoul, November (1997)
  95. Yun Jin Jung, Jeoung Soo Lee, Young Mi Kim, and Suk Kyu Han, Prodrugs of Colon-specific 5-Aminosalicylic Acid: Synthesis and Properties of Dextran-5-(4-Ethoxycarbonyl -phenylazo) Salicylic Acid Ester. The 45th Annual Convention of The Pharmaceutical Society of Korea, Seoul, October (1996)
  96. Neung Jin Ha, Yun Taek Kim, Jeoung Soo Lee, and Young Mi Kim, Formation and Antimicrobial Activities of Cotton Xanthate-Metal-Homosulfamine Complex. The 45th Annual Convention of The Pharmaceutical Society of Korea, Seoul, October (1996)
  97. Jeoung Soo Lee, Yun Jin Jung, Neung Jin Ha, and Young Mi Kim, Development of Cotton Derivatives with Antimicrobial Action. The 42nd Annual Convention of The Pharmaceutical Society of Korea, Seoul, October (1994)

Patents

  1. US 10,232,050: Multi-functional particle and methods of using the same
    (Jeoung Soo Lee)
  2. EP 2211727 B1: Cyanoacrylate tissue adhesives
    (Jeoung Soo Lee, Charles Kenneth Webb, Robert Zimmerman, and Rafael Ruiz)
  3. US 8613952: Cyanoacrylate tissue adhesives
    (Jeoung Soo Lee, Charles Kenneth Webb, Robert Zimmerman, and Rafael Ruiz)
  4. US 6248360: Complexes to improve oral absorption of poorly absorbable antibiotics
    (Seung Ho Choi and Jeoung Soo Lee): Licensed by Cubist Pharmaceuticals
  5. US 7527807: Compositions and methods for increasing the oral absorption of antimicrobials
    (Seung Ho Choi, Jeoung Soo Lee, and Dennis Keith)
  6. AU 2001/267011 B2: Compositions and methods to improve the oral absorption of antimicrobial agents
    (Seung Ho Choi, Jeoung Soo Lee, and Dennis Keith)
  7. EP 2263654 (A1): Compositions and methods to improve the oral absorption of antimicrobial agents
    (published on 12-22-2010; Seung Ho Choi, Jeoung Soo Lee, and Dennis Keith)

Ongoing Research

  1. Pilot project        8/15/2022~8/14/2023
    Establishment of feline SCI model and new MR imaging capabilities for assessment of therapeutic efficacy
    Agency: SC-BioCRAFT, Clemson/NIGMS
    Role: PI
  2. BX000347-11        1/15/2022~1/14/2026
    “Cerebral arteriole structure/function in diabetic ischemic brain injury”
    Agency: Veterans Administration
    Role: Collaborator (PI: Dr. Adviye Ergul, MUSC)
  3. USAMRMC H_002_2020        8/15/2020~8/14/2024
    “Point-of-Injury Application of Hydrogel Embedded Drugs for Severe Traumatic Brain Injury”
    Agency: U.S. Army Medical Research and Materiel Command
    Role: co-PI (PI: Dr. Sindhu Madathil in Walter Reed Army Institute of Research)
  4. R01 NS111037-01        2/1/2019~1/31/2023
    "Neuron-specific Nanotherapeutics for Spinal Cord Injury Repair"
    Agency: NIH/NINDS R01
    Role: PI
  5. 1R21 1R21NS114723-01A1        9/1/2020~8/31/2023
    “Preclinical Evaluation of Combination Therapy of Rolipram and Minocycline for Arresting Secondary Injury Cascade After Traumatic Brain Injury”
    Agency: NIH/NINDS
    Role: Co-investigator (PI: Dr. Murray, Louisiana Tech University)
  6. 1R21 1R21NS118224-01        9/1/2020~8/31/2023
    “Microglial RGS10 as a therapeutic target for Lewy body diseases”
    Agency: NIH/NINDS
    Role: Co-investigator (PI: Dr. Jae-Kyung Lee, UGA)