The Gilbert Biomaterials and Regenerative Medicine Laboratory


PUBLICATIONS

Peer Reviewed Scientific Papers

  1. Clarken-Wright G, Parvizi J, Lee GC, Klein GR, Rimnac CM, Gilbert JL, Kurtz, SM, “Titanium Alloy Sleeves do not Prevent Fretting Corrosion in Modular THA”, Orthop Proc, Jan, 2016. Full Text
  2. Kocagoz SB, Underwood RJ, MacDonald DW, Gilbert JL, Kurtz SM, “Ceramic Heads Decrease Metal Release Caused by Head-Taper Fretting and Corrosion”, Clin Orthop and Rel Res, (2016) 474: 985-994. Full Text, Erratum
  3. Niepa THR, Snepenger LM, Wang H, Sivan S, Gilbert, JL, Jones MB, Ren D, “Sensitizing Pseudomonas Aeruginosa to Anitbiotics by Electrochemical Disruption of Membrane Functions”, Biomaterials, Vol. 74, Jan 2016, pp 267-279. Abstract
  4. Morlock MM, Bunte D, Ettema H, Verheyen C, Hamberg A, Gilbert JL, “Primary Hip Replacement Stem Taper Fracture due to Corrosion – A case series of three patients”, Acta Orthopaedica, 2016; 87(2): 189-192. Full Text
  5. Kim J, Gilbert JL. "Cytotoxic effect of galvanically coupled magnesium–titanium particles", Acta Biomaterialia. 2016 Jan 15; 30: 368-77. Abstract
  6. Gilbert JL, Mali SA, Liu Y, “Area-Dependent Impedance Based Voltage Shifts During Tribocorrosion of Ti-6Al-4V Biomaterials: Theory and Experiment”, IOP Surface Topography: Metrology and Properties, Special Topic Issue: Surfaces and interfaces in bioengineering systems”, May, 4 (2016) 034002, pp 1-18. Abstract
  7. Niepa THR, Wang H, Dabrowiak JC, Gilbert JL, Ren D, “Probing the Synergy Between Tobramycin and Trivalent Chromium Ion in Electrochemical Control of Pseudomonas Aeruginosa”, Acta Biomat, Vol. 36, 286-295, 2016. Abstract
  8. Gilbert JL, “The Arc of Scientific Journals – Fifty Years of Publishing: 1985 – 2035”, J Biomed Mat Research – Part B, January, 2016, Vol. 104, No 1, pp 7.
  9. Ouellette ES, Gilbert JL, “Properties and Corrosion Performance of Self-Reinforced Composite PEEK for use as Modular Taper Gaskets”, Clin Ortho and Rel Res, Nov. 2016, Vol. 474, (11), pp 2414-2427. Full Text
  10. Higgs GB, MacDonald DW, Chen AF, Klein GR, Hamlin BR, Lee GC, Cates HE, Malkani AL, Kraay MJ, Gilbert JL, Rimnac CM, Kurtz SM, “Does Taper Size Have an Effect on Taper Damage in Retrieved Metal-on-Polyethylene Total Hip Devices?”, J Arthroplasty, Volume 31, Issue 9, Supplement, September 2016, Pages 277–281. Full Text
  11. Laurindo CAH, Bemben LM, Torres RD, Mali SA, Gilbert JL, “Influence of annealing treatment on the tribocorrosion properties of Ca and P containing Ti02 produced by plasma electrolytic oxidation”, Materials Technology, Vol. 31, No. 12(B1), 2016, pp 719-725. Abstract
  12. Arnholt C, M, MacDonald DW, Malkani AL, Kliein GR, Rimnac CM, Kurtz SM, Kocagoz SB, Gilbert JL, “Corrosion Damage and Wear Mechanisms in Long-term Retrieved CoCr Femoral Components for Total Knee Arthroplasty”, J of Arthoplasty, 31; 2016: 2900-2906. Full Text
  13. Mali SA, Singh V, Gilbert JL,"Effect of Mixed Alloy Combinations on Fretting Corrosion Performance of Spinal Screw and Rod Implants”, J Biomed Mat Res – Part B: Applied Biomat, Vol. 105, No. 5, July 2017, pp 1169-1177. Abstract
  14. Niepa, THR, Wang H, Gilbert JL, Ren D, “Eradication of Pseudomonas aeruginosa cells by cathodic electrochemical currents delivered with graphite electrodes", Acta Biomat, Vol 51, March 2017, pp 344-352. Full Text
  15. Liu Y, Gilbert JL, “The Effect of Simulated Inflammatory Solutions and Fenton Chemistry on the Electrochemistry of CoCrMo Alloy”, J Biomed Mat Res Part B: Appl Biomat, 10.1002/jbm.b.33830, Jan 24, 2017. Abstract
  16. Kubacki GW, Sivan S, Gilbert JL, “Electrocautery Induced Damage to Metal Implant Surfaces”, The Journal of Arthroplasty, June 16, 2017, Vol. 32, Issue 11, p3533–3538. Abstract
  17. Ouellette E, Shenoy A, Gilbert JL, “The seating mechanics of head-neck modular tapers in vitro: Load-displacement measurements, design, moisture and rate effects”, J Ortho Res, August 2017, DOI: 10.1002/jor.23725. Abstract
  18. Singh V, Shorez J, Mali S, Hallab N, Gilbert JL, “Material dependent fretting corrosion in spinal fusion devices: Evaluation of onset and long term response”, JBMR-B, in press, Dec. 2017, DOI: 10.1002/jbm.b.34067. Abstract
  19. Kubacki GM, Hui T, Gilbert JL, "Voltage and Wear Debris from Ti-6Al-4V Interact to Affect Cell Viability During In-Vitro Fretting Corrosion”, J Biomed Mat Res – Part A, August 2017, DOI: 10.1002/jbm.a.36220. Abstract
  20. Liu Y, Gilbert JL, “The effect of simulated inflammatory conditions and pH on fretting corrosion of CoCrMo alloy surfaces”, Wear, Vol. 390–391, 15 November 2017, pp 302-311. Abstract
  21. Gilbert JL, “Corrosion in the Human Body: Metallic Implants in the Complex Body Environment” Corrosion, August 2017, doi.org/10.5006/2563.
  22. Higgs GB, MacDonald DW , Lowell J, Padayatil A, Mihalko WM, Siskey RL, Gilbert JL Rimnac CM, Kurtz SM, “Is Corrosion a Threat to the Strength of the Taper Connection in Femoral Components of Total Hip Replacements?” Corrosion Journal, 2017, doi.org/10.5006/2632.
  23. Pierre D, Swaminathan V, Scholl L, TenHuisen K, Gilbert JL, “Effects of Seating Load Magnitude on Incremental Cyclic Fretting Corrosion in 12/14 Modular Taper Junctions", J Arthroplasty, In press, Feb. 2, 2018 doi.org/10.1016/j.arth.2018.01.039. Abstract
  24. Kim J, Gilbert JL, “The effect of cell density, proximity and time on the cytotoxicity of Mg and galvanically coupled Mg-Ti particles in vitro”, J Biomed Mat Rese – Part A, DOI: 10.1002/jbm.a.36334, Jan., 2018. Abstract
  25. Kim J, Gilbert JL, “In-Vitro Cytotoxicity of Galvanically Coupled Magnesium-Titanium Particles on Human Osteosarcoma SAOS2 Cells: A Potential Cancer Therapy”, J Biomed Mat Res – Part B, DOI:10.1002/jbm.b.34109, 2018. Abstract
  26. Liu Y, Gilbert JL, “Effect of Simulated Inflammatory Conditions and Potential on Dissolution and Surface Oxide of CoCrMo alloy: In Situ Electrochemical Atomic Force Microscopy Study”, Electrochemica Acta, https://doi.org/10.1016/j.electacta.2017.12.151, 2018. Abstract
  27. Scholl L, Pierre D, Lee R, Faizan A, Swaminathan V, TenHuisen K, Gilbert JL, Nevelos J, “Effect of the support systems’ compliance on total hip modular taper seating stability”, Part H: Journal of Engineering in Medicine, 2018, Vol. 232(9), pp 862-870. Abstract
  28. Wiegand MJ, Kubacki GW, Gilbert JL, “Electrochemical potential zone of viability on CoCrMo surfaces is affected by cell type: Macrophages under cathodic bias are more resistant to killing”, J Biomed Mat Res – Part A, September, 2018, 10.1002/jbm.a.36567. Abstract
  29. Kubacki GW, Gilbert JL, “The effect of the inflammatory specie hypochlorous acid on the corrosion and surface damage of Ti-6Al-4V and CoCrMo alloys”, J Biomed Mat Res – Part A, December 2018, 106(12):3185-3194. doi: 10.1002/jbm.a.36513. Abstract
  30. Pierre D, Swaminathan W, Scholl, TenHuiseen K, Gilbert JL, “Effects of load magnitude and load orientation on seating mechanics of 5o40” mixed-alloy modular taper junctions”, J Biomech, October 2018, Doi.org/10.1016/j.jbiomech.2018.10.037. Full Text
  31. Gilbert JL, Zhu D, “A tribocorrosion model linking fretting mechanics, currents and potentials: Model development and experimental comparison”, submitted, Electrochemica Acta, October 2018.
  32. Ouellette ES, Mali S, Kim J, Grostefon J, Gilbert JL, “Design, Material and Seating Load Effects on in vitro corrosion performance of modular head-neck tapers”, J Arthroplasty 2019: 34(5): 991-1002. Abstract
  33. Liu Y, Zhu D, Pierre D, Gilbert JL. Fretting initiated crevice corrosion of 316LVM stainless steel in physiological phosphate buffered saline: Potential and cycles to initiation. Acta biomaterialia. 2019 Jul 30. Abstract
  34. Wiegand, MJ, Benton, TZ, Gilbert, JL. 2019. A fluorescent approach for detecting and measuring reduction reaction byproducts near cathodically-biased metallic surfaces: Reactive oxygen species production and quantification. Bioelectrochemistry 2019: 129: 235-241. Abstract

Invited Lectures

  1. Stevenson Lecture, Metals and the Body, Syracuse University, March 4, 2016.
  2. Tribocorrosion of Orthopedic Implants: Mechanisms and Consequences, Department of Mechanical and Aerospace Engineering, Syracuse, University, April 1, 2016.
  3. University of Minnesota, Department of Materials Science and Engineering, Symposium on Hard Biomaterials, June 1, 2016.
  4. Clemson University, June 10, 2016.
  5. 2017 ORS Workshop: Taper Corrosion in THA: Clinical Impact and Applying the Best Evidence into Practice, Do Taper Materials and Designs Matter?, 2017 ORS meeting, San Diego, CA, 2017.
  6. Society of Vacuum Coaters, April, Providence, RI, April 29 – May 4, 2017.
  7. Othopedic Grand Rounds, Hospital for Special Surgery, “Can we Talk Tapers”, May 17, 2018.
  8. Hospital for Special Surgery, Bioengineering Division Lecture: “Can We Talk Engineering of Tapers?”, May 17, 2018.
  9. Exponent, Inc., Philadelphia, PA, July 12, 2018, “Inflammatory Cell Induced Corrosion: Current concepts in the link between biology and corrosion of metallic biomaterials".
  10. Presidential Lecture, The Hip Society, Las Vegas, March 2019.
  11. NACE Keynote Address to BioMaterials Symposium, March 26, 2019.
  12. Society For Biomaterials Invited Talk, April 5, 2019.
  13. STLE Keynote on BioTribology, May 22, 2019.

Extended Abstracts, Non-Refereed Papers and Conference Proceedings

  1. Shenoy, A & Gilbert, J. "Near-Field Electrochemical Impedance Spectroscopy Methods for Retrieval Surface Analysis". ISTA Annual Meeting, Toronto, CA, 2019.
  2. Smith, SM & Gilbert, JL. "The role of contact mechanics on the fretting corrosion performance of PEEK-metal taper junctions". 4th Annual International PEEK Meeting, Washington, DC, 2019.
  3. Smith, SM & Gilbert, JL. "Compliant interfaces and fretting corrosion in modular taper junctions: the micromechanics of contact". Annual Meeting of the Society for Biomaterials, Seattle, WA, 2019.
  4. Zhu D, Smith SM, Pierre D, Gilbert JL, Chinn J. “Effect of Multipurpose Care Solutions Upon Physical Dimensions of Silicone Hydrogel Contact Lenses”. Annual Meeting of the Society for Biomaterials, Seattle, WA, 2019.
  5. Smith, SM & Gilbert, JL. "Compliant interfaces and fretting corrosion in modular taper junctions: micromechanics and surface damage". Annual Meeting of Orthopedic Research Society, Austin, TX, 2019.
  6. Zhu D, Khullar P, Gilbert JL. “Long-term Fretting Corrosion Behavior of Si3N4/Ti-6Al-4V Head Neck Taper Interface”. Annual Meeting of the Orthopedic Research Society, Austin, TX, 2019.
  7. Gilbert JL, Zhu D, Smith SM, Pierre D. “A Model of Taper Seating Impaction: Head Size, Substrate Stiffness and Impulse Effects”. Annual Meeting of the Orthopedic Research Society, New Orleans, LA, 2018.
  8. Gilbert JL, Li Z, Zhu D, Kubacki GW. “Tribocorrosion Heredity Integral Modeling of Abrasion-Current-Impedance-Voltage Relationships”. Annual Meeting of the Society for Biomaterials, Minneapolis, MN, 2017.
  9. Zhu D & Gilbert JL. “Development of a “2-D” Test System for Visualizing Fretting Corrosion: A Study of the Fretting Corrosion Behavior of CoCrMo Alloy”. Annual Meeting of the Orthopedic Research Society, San Diego, CA, 2017.
  10. Ouellette E, Shenoy AA, Gilbert JL, “Seating Load-Displacement Mechanics of Modular Tapers: Influence of seating load, loading rate, moisture and design parameters on pull-off”, World Biomaterials Congress, 2016.
  11. Kubacki GW, Gilbert JL, “Electrocautery induced damage to Ti-6Al-4V and CoCrMo alloy surfaces in vivo and in vitro: An additional damage source to inflammatory cell induced corrosion”, Int Soc for Technology in Arthoplasty, Oct, 2016.
  12. Gilbert JL, Mali SA, Kim J, Grostefon J, “An assessment of seven design, material and surgical factors on the fretting corrosion of head-neck modular taper junctions: A multifactorial design of experiment study”, Int Soc for Technology in Arthoplasty, Oct, 2016.
  13. Pierre D, Swaminathan V, School L, TenHuisen K, Leee R, Gilbert, JL, “Effects of load magnitude and orientation on seating mechanics in modular taper junctions”, Int Soc for Technology in Arthoplasty, Oct, 2016.
  14. Arnholt C, MacDonald D, Lowell J, Gilbert JL, Hihalko W, Kurtz SM, “Metal release and damage mechanisms in authopsy total knee arthroplasty femoral components”, ISTA, October 3, 2016.
  15. Al-Hajjar M, Groves D, Williams S, Fished J, Thompson J, Gilbert, JL, “Effect of articulation and edge loading on taper wear and corrosion in total hip replacement”, Trans 2017 ORS.
  16. Pierre D, Swaminathan V, Scholl L, Lee R, Faizan A, TenHuisen K, Gilbert JL, “Effects of seating load orientation on incremental cyclic fretting corrosion in 5o40’ modular taper junctions”, Trans ORS 2017.
  17. Pierre D, Swaminathan V, Scholl L, Lee R, Faizan A, TenHuisen K, Gilbert JL, “Effects of seating load magnitude on incremental cyclic fretting corrosion in 5o40’ modular taper junctions”, Trans ORS 2017.
  18. Zhu D, Gilbert JL, “Development of a 2-D test system for visualizing fretting corrosion: a study of the fretting corrosion response of CoCrMo alloy”,Trans ORS, 2017.
  19. Kubacki G, Liu Yangping, Gilbert JL, “The Effects of the Inflammatory Species Hypochlorous Acid on the Electrochemical Behavior of Co-Cr-Mo Alloys”, Trans ORS, 2017.
  20. Arnholt C, MacDonald D, Lowell J, Gilbert JL, Mihalko WM, Kurtz SM, “Metal Release and Damage Mechanisms in Autopsy Total Knee Arthroplasty Femoral Components”, ASTM Symposium, May 2017.
  21. Wiegand MJ, Kubacki GM, Gilbert JL, “Electrochemical induced cell death of monocyte inflammatory cells on CoCrMo alloy in vitro”, Trans Soc for Biomat 2017.
  22. Gilbert JL, Li Z, Zhu D, Kubacki GW, “Tribocorrosion Heredity Integral Modeling of Abrasion-Current-Impedance-Voltage Relationships”, Trans Soc for Biomat, 2017.
  23. Gilbert JL, Shenoy A, “Bio-metallurgical interactions during in vivo corrosion: Beyond fretting corrosion, a study of the forms of corrosion in retrieved modular implants, their causes and consequences”, ASTM Symposium, May, 2017.
  24. Gilbert,JL, Lin J, “An Electrochemical Impedance Method for In-Situ Analysis of Corrosion State of Localized Modular Taper Implant Surfaces”, ASTM Symposium, May, 2017.
  25. Pierre D, Gilbert JL, “The seating mechanics and pull-off strength of contaminated 5 degree 40 minute modular tapers”, Trans ORS, p 969, 2018.
  26. Wiegand MJ, Gilbert JL, “Direct conversion and detection of reactive oxygen species on a cathodically-biased metallic surface”, Trans ORS, 987, 2018.
  27. Higgs GB MacDonald DW, Lowell J, Padayatil, A, Mihalko W, Siskey RL, Gilbert JL, Rimnac CL, Kurtz SM, “Does corrosion loosen the taper connection of femoral components in total hip repalcements”, Trans ORS, 276, 2018.
  28. Pierre D, Gilbert JL, “Effects of Taper Junction Contamination on Corrosion and Micromotion During Incremental Cyclic Fretting Corrosion Testing of 5 deg 40' Modular Taper Junctions”, Trans ORS, 1858, 2018.
  29. Shenoy A, Gilbert JL, “A Modular Acetabular Test Method to Assess Shell-Liner Taper Seating and Fretting Corrosion Behavior” Trans ORS, 2018.
  30. Gilbert JL, Zhu D, Smith S, Pierre D, “A Model of Taper Seating Impaction: Head Size, Substrate Stiffness and Impulse Effects ”, Trans ORS, 2018.
  31. Wiegand MJ, Gilbert JL, “Direct detection of fluorescently-tagged reactive oxygen species on a cathodically-biased metallic surface” Trans Soc for Biomat, 2018.
  32. Pierre, D, Gilbert, JL, “Fretting initiated crevice corrosion of 316L stainless steel”, ISTA, London, 2018.
  33. Shenoy, A, Kurtz SM, Gilbert JL, “Corrosion Mechanisms in Retrieved Acetabular Modular Tapers”, ISTA, London, 2018.
  34. Higgs, G, Gilbert JL, Kurtz, SM, “Electrochemical Method to Assess Corrosion Severity in Modular Tapers”, ISTA, London, 2018.
  35. Wiegand, MJ, Littlejohn S, Gilbert JL, “Sensing surface damage of CoCrMo alloys and taper retrievals using nearfield electrochemical impedance spectroscopy”, to be presented, ORS, 2019.
  36. Aslan C, Gilbert JL, “A preliminary Electrochemical and Ion Release Assessment of the Essure Medical Device”, to be presented at the Soc. For Biomat., 2019.
  37. Smith S, Gilbert JL, “Compliant Interfaces and Fretting Corrosion in Modular Taper Junctions: The Micromechanics of Contact”, ORS, 2019, to be presented.
  38. Zhu D, Khullar P, Gilbert JL, “Long-term Fretting Corrosion Behavior of Si3N4/Ti-6Al-4V Head Neck Taper Interface”, ORS, 2019, to be presented.
  39. Smtih S, Gilbert JL, “Contact Mechanics and Fretting Corrosion Performance of PEEK and orthopaedic implant alloys: Preventing fretting corrosion damage in metallic orthopaedic implants: contact mechanics”, Peek Conference
  40. Smith S, Gilbert JL, “Compliant Interfaces and Fretting Corrosion in Modular Taper Junctions: The Micromechanics of Contact”, to be presented at Soc For Biomat., 2019.

Patents and Invention Disclosures

  1. Orthopedic Implant with Self-Reinforced Mantle, Patent # 5,507,814, Issued, April 16, 1996.
  2. Methods of Making Self-Reinforced Compositions of Amorphous Thermoplastics, Patent #5,679,299, October 27, 1997.
  3. Bone Cement and Method of Preparation, Patent # 5,902,839, May 11, 1999.
  4. Method of preparing Biomedical Surface, Patent #8,012,338, September 6, 2011.
  5. Multisolution Bone Cement and Methods of Making the Same, Patent #8,383,734, Feb, 26, 2013.
  6. Multisolution Bone Cement and Methods of Making the Same, Patent #8,575,274, Nov 5, 2013.
  7. System and Method for Controlling Bacterial Persister Cells with Weak Electric Currents, Patent #8,569,027, October 29, 2013.
  8. System and Method for Controlling Bacterial Cells with Weak Electric Currents, Patent #8,663,914, March 4, 2014.
  9. Method for Preparing Biomedical Surfaces, Patent #8,876,910, Nov. 4, 2014.
  10. Electrochemical Coupling of Metallic Biomaterial Implants for Biological Effect, Patent # 9,039764, 5/26/2015.
  11. Electrochemical Eradication of Microbes on Surfaces of Objects, Patent #9616142, April 11, 2017.
  12. Prevention of Fretting Crevice Corrosion of Modular Taper Interfaces in Orthopedic Implants with serial No. 61/72 2,459, filed on 11/5/12.
  13. Smart Medical Devices for Electrochemical Monitoring and Control of Medical Implants, provisional patent, 3/15/2013.
  14. Use of Lipids for Preventing Fretting Corrosion in the Modular Tapers of Orthopedic Implants, Disclosure SU100883.