The Gilbert Biomaterials and Regenerative Medicine Laboratory

RESEARCH

The Gilbert Research Laboratory for Biomaterials and Regenerative Medicine


Jeremy L. Gilbert, Ph.D., F.B.S.E, Hansjorg Wyss Smart State Endowed Chair for Regenerative Medicine, Professor of Bioengineering Clemson University, Director Clemson – MUSC Bioengineering Program, Professor of Orthopaedics, MUSC.

The Gilbert Biomaterials and Regenerative Medicine Laboratory is located in the Clemson University – Medical University of South Carolina Program of Bioengineering, in the Bioengineering Building on the MUSC campus in Charleston SC. The work in our lab consists of studies related to biomaterials and medical devices, the biomaterials used to make these devices, tests to understand performance and fundamental interactions between biomaterials and the living system. The laboratory consists of about 2500 sq ft of research space with state-of-the-art facilities in biomaterials science testing, characterization, surface analysis, electrochemical behavior, cell culture and retrieval analysis. There are a number of capabilities within the laboratory that include mechanical testing (micro-, nano- and macro-), electrochemical and tribocorrosion testing (potentiostats, electrochemical impedance analysis, pin-on-disk fretting test systems), cell culture, imaging (SEM/EDS, DOM, AFM, Fluorescence, FTIR), surface analysis (XPS), implant retrieval analysis, metallurgical preparation and ion analysis (ICP-MS and AAS). The facilities are located within the basic life sciences and clinical research facilities on the MUSC campus which includes access to clinical faculty, animal care and use facilities and a world-class life sciences environment.

Collaboration with Medical Device Companies
A unique aspect of the Gilbert Lab, is its strong and continuously supported interactions with a wide range of medical device companies in working to design, develop, test and assess medical devices and the biomaterials used to make them. These collaborations have assisted in development of new state-of-the-art implant test methods, development of new technologies for medical therapeutics, and exploration of fundamentally new scientific fields related to biology and electrochemical interactions with metallic biomaterials. Implant retrieval analysis, medical device bench-top performance testing, fundamental biomaterials testing, surface analysis, biological interactions are all elements of the work done in the Gilbert Lab. A fundamental goal of the Gilbert Lab is to advance healthcare by working on real medical devices for real patients to understand clinical performance and the underlying fundamental engineering, materials science and biology related to device performance. Medical device areas currently under investigation include: Orthopedic implants, spinal implants, dental implants, cardiovascular implants, gynecological implants, Ophthalmological implants, as well as therapeutics for infection control and cancer treatment.

Please explore the pages and links in the remaining webpages to better learn about the efforts of the Gilbert Laboratory.

Recent focus of the Gilbert Laboratory includes:

Cell-Surface Interactions
Role of electrochemistry on cell viability and phenotype Metallic surface-cell interactions Anti-infection therapeutic approaches using reduction electrochemistry Anti-cancer electrochemical therapeutic approaches Inflammatory cell-metal interactions Mg/Ti Bimetallic Particle Interactions

Tribocorrosion Modeling, Testing and Analysis
Fretting Corrosion experiments and modeling for passive oxide film alloys in aqueous solutions Surface contact mechanics, indentation testing, friction, adhesion, surface modulus and hardness

Corrosion and Impedance Testing of Medical Alloys
EC-AFM of CoCrMo and Ti-6Al-4V EIS of alloys with Potential Dependence. Time-Domain Impedance Analysis Methods

Medical Device Testing and Test Method Development
Modular taper testing methods Contact lens test methods Surface Indentation, friction and adhesion testing

Implant Retrieval Analysis
Orthopedic and spinal implants Modular tapered implants and corrosion Cell-induced damage modes Metallic Implant-Tissue Analysis Electrocautery

Surfaces, Mechanics and Properties
Contact lens modulus, friction and adhesion

Gilbert CV