THE COTTLE GROUP
Principal Investigator: Dr. Renee Cottle
TEAM
Carly Radomski
Email: cradoms@g.clemson.edu
Education
Clemson University B.S. in Genetics
Expected Graduation: May 2027
Honors and Awards
Current Projects
Working under PhD student, Justin Gibson, I am assisting in generating a novel mouse model of familial hypercholesterolemia. The mouse model is a double homozygous Ldlr -/- and Fah -/- crossbreed. The goal of the project is to generate and characterize the mouse model to quantify levels of hepatocyte transplantation needed for familial hypercholesterolemia treatment. My current role in the project is to assist in tissue sample collection and genotyping of the mouse model offspring.
Email: cradoms@g.clemson.edu
Education
Clemson University B.S. in Genetics
Expected Graduation: May 2027
Honors and Awards
Current Projects
Working under PhD student, Justin Gibson, I am assisting in generating a novel mouse model of familial hypercholesterolemia. The mouse model is a double homozygous Ldlr -/- and Fah -/- crossbreed. The goal of the project is to generate and characterize the mouse model to quantify levels of hepatocyte transplantation needed for familial hypercholesterolemia treatment. My current role in the project is to assist in tissue sample collection and genotyping of the mouse model offspring.
Francesca Lucia Mango
Email: fmango@clemson.edu
Education
Clemson University
Expected graduation May 2028
Honors and Awards
Out of State Scholarship recipient, Honors College
Current Projects
Working with CRISPR-Cas9–mediated multiplex gene editing for ex vivo cell therapy in the treatment of familial hypercholesterolemia.
Email: fmango@clemson.edu
Education
Clemson University
Expected graduation May 2028
Honors and Awards
Out of State Scholarship recipient, Honors College
Current Projects
Working with CRISPR-Cas9–mediated multiplex gene editing for ex vivo cell therapy in the treatment of familial hypercholesterolemia.
Lane Broderick
Email: Lsbrode@g.clemson.edu
Education
Bachelors in Biological sciences student
Expected graduation May 2028
Honors and Awards
Dean’s list spring 2025
Presidents list fall 2025
S.C. Palmetto Fellows scholarship recipient
Current Projects
Comparative Safety Analysis of Multiplex CRISPR Systems for Ex Vivo
Hepatocyte Gene Editing in Familial Hypercholesterolemia
Email: Lsbrode@g.clemson.edu
Education
Bachelors in Biological sciences student
Expected graduation May 2028
Honors and Awards
Dean’s list spring 2025
Presidents list fall 2025
S.C. Palmetto Fellows scholarship recipient
Current Projects
Comparative Safety Analysis of Multiplex CRISPR Systems for Ex Vivo
Hepatocyte Gene Editing in Familial Hypercholesterolemia
Sacha Estel
Email: sestel@clemson.edu
Education
Bachelors in Genetics Student
Expected graduation 2027
Associates in science, Trident Technical College, 2024
Honors and Awards
Tigers on Track scholarship recipient
S.C. LIFE Scholar
Current Projects
Working with CRISPR/CAS-9 delivery into primary hepatocytes to treat familial hypercholesterolemia via ex vivo strategy
Email: sestel@clemson.edu
Education
Bachelors in Genetics Student
Expected graduation 2027
Associates in science, Trident Technical College, 2024
Honors and Awards
Tigers on Track scholarship recipient
S.C. LIFE Scholar
Current Projects
Working with CRISPR/CAS-9 delivery into primary hepatocytes to treat familial hypercholesterolemia via ex vivo strategy
Wynton Vaughn
Email: wyntonv@clemson.edu
Education
Bachelors in Bioengineering
Expected graduation May 2027
Honors and Awards
Current Projects
Safety and feasibility of ex vivo AAV mediated gene therapy for inherited metabolic liver diseases
Email: wyntonv@clemson.edu
Education
Bachelors in Bioengineering
Expected graduation May 2027
Honors and Awards
Current Projects
Safety and feasibility of ex vivo AAV mediated gene therapy for inherited metabolic liver diseases